A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Patients With Knee Osteoarthritis

Inclusion Criteria:

- Male patients or female patients of non-childbearing potential Age between 40 to 75
years (both inclusive).

- Body weight > 40 kg, body mass index (BMI) < 40 kg/m2.

- Diagnosed for knee osteoarthritis based on clinical and radiological criteria of the
American College of Rheumatology.

- History of knee pain for at least 6 months and on the majority of days (> 50%) during
the preceding month.

- Symptom severity defined by a pain ≥ 40 mm and ≤ 90 mm on VAS (100 mm).

- Documented need for symptomatic as needed-treatment for OA in the target knee with
systemic non-steroidal anti-inflammatory drugs (NSAIDs) and/or other analgesics

Exclusion Criteria:

- Severe clinical knee malalignment according to the investigator.

- Knee prosthesis already implanted (< 1 year) or not well-tolerated (contralateral
side).

- Knee prosthesis already foreseen within the study period (whichever side)

- Hip prosthesis recently implanted (< 1 year) or foreseen within the study period
(whichever side).

- Previous osteotomy on the inferior limbs (whichever side).

- Surgical operation on the target knee within the 12 months prior to the screening
visit or planned during the study.

- Arthroscopy of the target knee within the 6 months prior to the screening visit or
planned during the study.

- Other pathologies affecting the knee.

- Any contraindication to MRI including the inability to undergo a knee MRI exam because
of inability to fit in the scanner or knee coil.