Post Thrombotic Syndrome Prevention Study

The purpose of this study is to determine if use of a pneumatic compression device
(ACTitouch, Tactile Medical) is beneficial in improving or preventing the development of Post
Thrombotic Syndrome (PTS). 84 patients who have a history of an acute proximal unilateral leg
DVT diagnosed one or more months prior to enrollment, or diagnosed with a chronic proximal
unilateral leg DVT at time of enrollment, on duplex or other imaging study will be randomized
into two groups: the control group receiving the standard of care compression stockings and
the intervention group receiving ACTitouch device.

Inclusion Criteria:

- At least 18 years of age or older

- History of an acute proximal unilateral leg DVT diagnosed one or more months prior to
enrollment, or diagnosed with a chronic proximal unilateral leg DVT at time of
enrollment, on duplex or other imaging study (i.e MRV, CTV, venogram)

- Current anticoagulation therapy

- Physical ability to independently don ACTitouch or availability of help to place
device

Exclusion Criteria:

- Current diagnosis of PTS or PTS symptoms

- Diagnosis of acute DVT less than 30 days prior to enrollment

- History of prior ipsilateral DVT

- Chronic venous insufficiency (CVI) with a CEAP 4 or greater and/or noted changes in
the deep system during the diagnosing duplex

- Morbid Obesity (BMI > 45)

- Congestive heart failure with symptoms not controlled by medical intervention

- Pulmonary edema, active, with symptoms not controlled by medical intervention

- Peripheral artery disease (PAD) unless the patient has an ankle pressure of 60mmHg or
more

- Walking disability (immobile)

- Women who are pregnant or trying to become pregnant

- Any other condition in which compression would be contraindicated as determined by the
treating physician