MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal, Gastrointestinal, Hepatitis |
| Therapuetic Areas: | Gastroenterology, Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 6 - 23 |
| Updated: | 7/26/2018 |
| Start Date: | January 17, 2017 |
| End Date: | January 2021 |
| Contact: | Alexander Miethke, MD |
| Email: | alexander.miethke@cchmc.org |
| Phone: | 513-636-8948 |
Cross-sectional Study for Assessment of MRI Based Biomarkers of Bile Duct Injury and Hepatic Fibrosis in Pediatric Onset Autoimmune Liver Disease
Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and
Autoimmune Hepatitis (AIH) are a common etiological factors for chronic liver disease among
adolescents. In all these conditions, autoimmune lymphocyte responses are thought to
orchestrate inflammatory injury against hepatocytes (primarily in AIH) or cholangiocytes (in
PSC). In this proposal we aim to evaluate the Magnetic Resonance Imaging (MRI) modalities; MR
cholangiopancreatography (MRCP) and MR elastography (MREL), as non-invasive biomarkers to
assess two primary pathophysiological processes of AILD: bile duct damage and liver fibrosis.
In this cross-sectional study MRI based findings of bile duct injury and liver fibrosis will
be correlated with both liver histology and circulating biomarkers of these disease
processes.
Autoimmune Hepatitis (AIH) are a common etiological factors for chronic liver disease among
adolescents. In all these conditions, autoimmune lymphocyte responses are thought to
orchestrate inflammatory injury against hepatocytes (primarily in AIH) or cholangiocytes (in
PSC). In this proposal we aim to evaluate the Magnetic Resonance Imaging (MRI) modalities; MR
cholangiopancreatography (MRCP) and MR elastography (MREL), as non-invasive biomarkers to
assess two primary pathophysiological processes of AILD: bile duct damage and liver fibrosis.
In this cross-sectional study MRI based findings of bile duct injury and liver fibrosis will
be correlated with both liver histology and circulating biomarkers of these disease
processes.
Inclusion Criteria:
1. Age 6-23 years old.
2. Established or suspected clinical diagnosis of AIH or PSC.
Exclusion Criteria:
1. History of liver transplantation.
2. Chronic Hepatitis B or untreated hepatitis C virus infection.
3. Pregnancy.
4. Absolute contraindication for MRI (e.g. pacemaker, metallic implants, claustrophobia).
5. Diagnosis of cystic fibrosis or biliary atresia
6. Diagnosis of cardiac hepatopathy.
7. Diagnosis of Wilson's disease, Alpha-1 Antitrypsin deficiency, or Glycogen storage
disease.
8. Skin conditions which could be aggravated by MREL (i.e. Epidermolysis bullosa).
We found this trial at
1
site
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
Cincinnati, Ohio 45229
1-513-636-4200
Principal Investigator: Alexander Miethke, MD
Phone: 513-636-5581
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
Click here to add this to my saved trials
