A Study to Test if TEV-50717 is Effective in Relieving Tics Associated With Tourette Syndrome

Inclusion Criteria:

- Patient weighs at least 44 pounds (20 kg) at baseline.

- Patient meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
(DSM-5™) diagnostic criteria for TS and, in the opinion of the investigator, patient,
and parent/legal guardian, the patient's active tics are causing distress or
impairment.

- Patient has a TTS of 20 or higher on the YGTSS at screening and baseline.

- Patient is able to swallow study medication whole.

- -Additional criteria apply, please contact the investigator for more information

Exclusion Criteria:

- Patient has a neurologic disorder other than TS that could obscure the evaluation of
tics.

- The patient's predominant movement disorder is stereotypy (coordinated movements that
repeat continually and identically) associated with autism spectrum disorder.

- Patient has clinically significant depression at screening or baseline.

- Patient has a history of suicidal intent or related behaviors within 2 years of
screening

- Patient has a history of a previous actual, interrupted, or aborted suicide attempt.

- Patient has a first-degree relative who has completed suicide.

- Patient has a confirmed diagnosis of bipolar disorder, schizophrenia, or another
psychotic disorder.

- Patient has received Comprehensive Behavioral Intervention for Tics for TS or
Cognitive Behavioral Therapy for OCD within 4 weeks of screening.

- Patient has received treatment with deep brain stimulation, transmagnetic stimulation,
or transcranial direct current stimulation within 4 weeks of the screening visit for
reduction of tics.

- Patient has a history of torsades de pointes, congenital long QT syndrome,
bradyarrhythmias, or uncompensated heart failure.

- Patient has participated in an investigational drug or device study and received
IMP/intervention within 30 days or 5 drug half-lives of baseline, whichever is longer.

- Patient is a pregnant or lactating female, or plans to be pregnant during the study.

- -Additional criteria apply, please contact the investigator for more information