CHOCOlate MeLatonin for AdolescenT MigrainE

This pilot randomized trial is a dose-finding study to determine which dose of melatonin is
most effective for treating acute migraine in children and adolescents who have episodic
migraine. We will identify the most effective dose to pull forward into a future
fully-powered placebo-controlled efficacy study. If both doses are equally effective, we will
bring forward the best tolerated dose. If doses are equally well tolerated, we will bring
forward the lowest effective dose, as this will minimize cost to families should this
treatment become widely adopted.

Inclusion Criteria:

1. Meet ICHD criteria for episodic migraine in children and adolescents, with at least 1
migraine attack per month on average.

2. Age 3-17 years

3. Dissatisfaction with previous acute treatments, for one or more of the following
reasons: a) One or more previously tried acute medications have not been effective, or
adequately effective, b) previously tried acute treatments have caused side effects,
or C) patient/family would prefer a natural supplement for acute treatment over
medication treatment

4. If of driving age, teen participant agrees not to drive for at least 8 hours after
treating with melatonin.

Exclusion Criteria:

1. Allergy or intolerance to melatonin, or to chocolate.

2. Opioid or barbiturate overuse as defined in ICHD

3. Pregnant/lactating