Analysis of B Cells From Autoimmune Individuals
| Status: | Recruiting |
|---|---|
| Conditions: | Arthritis, Lupus, Rheumatoid Arthritis, Diabetes |
| Therapuetic Areas: | Endocrinology, Immunology / Infectious Diseases, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 7/28/2018 |
| Start Date: | May 2016 |
| End Date: | May 2026 |
| Contact: | Roberta Pelanda, PhD |
| Email: | roberta.pelanda@ucdenver.edu |
| Phone: | 303-724-8666 |
This observational study aims at finding out if individual with autoimmunity exhibit
increased numbers of B cells that express two types (instead of one type) of antibodies, and
if B cells of individuals genetically susceptible to autoimmunity display defects in the
biological process of tolerance, which removes B cells that participate in autoimmunity.
increased numbers of B cells that express two types (instead of one type) of antibodies, and
if B cells of individuals genetically susceptible to autoimmunity display defects in the
biological process of tolerance, which removes B cells that participate in autoimmunity.
Inclusion Criteria:
- Adult Males and Females diagnosed with Lupus;
- Adult Females who are pregnant and diagnosed with:
- lupus erythematosus
- rheumatoid arthritis, or
- type 1 diabetes.
Exclusion Criteria:
- Adult males or adult females treated with B-cell depletion therapies.
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