Deep Brain Stimulation in Patients With LUTS

Deep brain stimulation (DBS) is a neurosurgical procedure that improves motor symptoms of
specific neurological and movement disorders such as Parkinson's disease or Essential Tremor.
DBS is implanted when symptoms cannot be satisfactorily controlled with medications or
conventional therapies. After insertion of deep electrodes, electrical stimulation will be
delivered to modulate specific neurons in certain areas of the brain. Despite, the known
motor effects for DBS, its nonmotor effects on other organs such as the urinary tract and
bladder function remains unclear. Lower urinary tract symptoms such as frequency, urgency,
urinary incontinence, or incomplete bladder emptying are common in patients who have
underlying neurological or movement disorders. In addition, central neural control over lower
urinary tract function is still poorly understand. In this trial investigators plan to
evaluate the effects of Deep Brain Stimulators (DBS) on lower urinary tract function. This
trial is designed to test the hypothesis that DBS improves objective and subjective symptoms
of lower urinary tract function in specific patient populations. The investigators plan to
test this hypothesis by using validated patient reported outcome questionnaires and
urodynamic testing (both are part of routine care for neurogenic bladder) before and after
DBS implantation. In addition, this trial will shed some light in understanding higher neural
control of bladder and potentially identify target areas for future intervention.

Inclusion Criteria:

- Patients who are a candidate for Deep Brain Stimulation (DBS) as standard care for
neurologic symptoms and have a moderate or greater urinary bother American Urological
Association Symptom Score (AUASS≥8)

Exclusion Criteria:

- Pregnant, breastfeeding mothers and all individuals younger than 18 years of age will
be excluded. Patients with history of urinary diversion or augmentation cystoplasty
will also be excluded.