Stimulation of the Rostral Zona Incerta for Parkinson's Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 7/27/2018 |
| Start Date: | July 3, 2017 |
| End Date: | October 2020 |
| Contact: | Pamela David Gerecht, PhD |
| Email: | pamela.davidgerecht@ucdenver.edu |
| Phone: | 303-724-4134 |
Deep Brain Stimulation (DBS) of the Rostral Zona Incerta (rZI) for Parkinson's Disease (PD): Clinical Efficacy and Evaluation of Adverse Effects
Patients with Parkinson's Disease who undergo Deep Brain Stimulation surgery receive symptom
relief due to electrical stimulation of the brain. The target for the stimulation, in many
cases, is the subthalamic nucleus (STN). The brain area just above the STN is called the
rostral Zona Incerta (rZI). The rZI may be a potential target for deep brain stimulation, in
combination with the STN.
relief due to electrical stimulation of the brain. The target for the stimulation, in many
cases, is the subthalamic nucleus (STN). The brain area just above the STN is called the
rostral Zona Incerta (rZI). The rZI may be a potential target for deep brain stimulation, in
combination with the STN.
Deep brain stimulation (DBS) of an area of the brain called the subthalamic nucleus (STN) is
an effective treatment in Parkinson's disease (PD). However, stimulating the STN can lead to
unwanted side effects that involve muscle movements (dyskinesias) and behavior and mood
problems. DBS of a different brain structure, called the rostral zona incerta (rZI), has been
demonstrated to be as effective as stimulating the STN, without any unwanted side effects in
several studies. However, there is great variability in reported efficacy and adverse effects
of rZI stimulation likely due to challenges in locating this area in the brain. The goals of
this study are 1) to develop an improved method for targeting the rZI 2) determine efficacy
of rZI with STN stimulation compared with STN stimulation alone, 3) evaluate any stimulation
adverse effects of combined stimulation of the rZI and STN.
an effective treatment in Parkinson's disease (PD). However, stimulating the STN can lead to
unwanted side effects that involve muscle movements (dyskinesias) and behavior and mood
problems. DBS of a different brain structure, called the rostral zona incerta (rZI), has been
demonstrated to be as effective as stimulating the STN, without any unwanted side effects in
several studies. However, there is great variability in reported efficacy and adverse effects
of rZI stimulation likely due to challenges in locating this area in the brain. The goals of
this study are 1) to develop an improved method for targeting the rZI 2) determine efficacy
of rZI with STN stimulation compared with STN stimulation alone, 3) evaluate any stimulation
adverse effects of combined stimulation of the rZI and STN.
Inclusion Criteria:
- Parkinson's Disease,
- No current deep brain stimulating electrodes
Exclusion Criteria:
- Other movement disorders,
- Parkinson's Disease with already implanted electrode.
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