Vibration for Muscle Spasms After Spinal Cord Injury
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Hospital, Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 11/30/2018 |
| Start Date: | June 30, 2017 |
| End Date: | June 30, 2023 |
| Contact: | Monica Perez, PhD, PT |
| Email: | perezmo@miami.edu |
| Phone: | 305-243-7119 |
Closed Loop Control of Vibration for Muscular Spasms After Human Spinal Cord Injury: Efficacy and Mechanism
This study uses closed-loop control of tendon vibration to implement clinically meaningful
management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms
responsible for spasm generation change in response to vibration.
management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms
responsible for spasm generation change in response to vibration.
The specific aims of this study are listed below:
1a) Evaluate the ergonomics of the wearable device that will be used to record and detect
spasms, then to deliver vibration to tendons to dampen spasms.
1. b) Determine the vibration parameters that best reduce spasms in leg muscles paralyzed
by spinal cord injury (SCI) in the laboratory using the wearable device.
2. a) Examine the efficacy of tendon vibration in altering muscle spasms by treating spasms
as they occur in real world environments using 24-hour electromyographic (EMG)
recordings.
Hypothesis 2a: Achilles tendon vibration will dampen spasms acutely, and may alter their
distribution Assess excitatory and/or inhibitory mechanisms that underlie spasms, and changes
induced with vibration, by recording physiological, clinical, functional and self-reported
measures of different aspects of spasticity, and health-related quality of life, before and
after conditioning spasms with vibration. These data will provide insight into the site(s),
magnitude, and time-course of changes with vibration; and user perspective on the effects of
the therapy.
Achilles tendon vibration will dampen spasms by reconfiguring circuits generating 6-13 Hz
shared drive to motoneurons.
1a) Evaluate the ergonomics of the wearable device that will be used to record and detect
spasms, then to deliver vibration to tendons to dampen spasms.
1. b) Determine the vibration parameters that best reduce spasms in leg muscles paralyzed
by spinal cord injury (SCI) in the laboratory using the wearable device.
2. a) Examine the efficacy of tendon vibration in altering muscle spasms by treating spasms
as they occur in real world environments using 24-hour electromyographic (EMG)
recordings.
Hypothesis 2a: Achilles tendon vibration will dampen spasms acutely, and may alter their
distribution Assess excitatory and/or inhibitory mechanisms that underlie spasms, and changes
induced with vibration, by recording physiological, clinical, functional and self-reported
measures of different aspects of spasticity, and health-related quality of life, before and
after conditioning spasms with vibration. These data will provide insight into the site(s),
magnitude, and time-course of changes with vibration; and user perspective on the effects of
the therapy.
Achilles tendon vibration will dampen spasms by reconfiguring circuits generating 6-13 Hz
shared drive to motoneurons.
Inclusion Criteria:
- Men and women
-1) Individuals with spinal cord injury (SCI)
- Individuals with chronic (> 1 year) traumatic cervical or thoracic SCI
- Participants with classification A (motor and sensory complete), B (motor complete and
sensory incomplete) or C (motor complete and sensory incomplete; provided there is no
voluntary control of muscles in at least one leg)
- Participants who report problematic muscle spasms
-2) Able-bodied participants
- Individuals with no known neurological disorder
Exclusion Criteria:
- SCI participants with known head injury
- SCI participants with neurological disorder other than SCI
- SCI participants with severe systemic disorder (liver, kidney, heart failure), drug or
alcohol abuse or who are unable to give informed consent.
- Able-bodied participants with a neurological condition
This information will be obtained by self-report.
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