Hypertension Chronobiome
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/27/2018 |
| Start Date: | July 16, 2018 |
| End Date: | May 31, 2023 |
| Contact: | LaVenia Banas, CRN |
| Email: | banas@pennmedicine.upenn.edu |
| Phone: | 2156624652 |
Non-dipping Hypertension and the Human Chronobiome
Hypertension is a common condition with a concomitant burden of stroke, kidney disease and
myocardial infarction. Its prevalence in developed societies is increasing as they age, and
in less developed countries, as their populations assume aspects of the Western diet and
lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to
dip at night - is estimated to complicate ~40% of hypertensives and is associated with poor
outcomes. Randomized controlled trials have shown that a reduction of daytime systolic blood
pressure by as little as 5mmHg on average (towards a target of 140mmHg) translates into a
measurable clinical benefit. The peak nocturnal difference may be ~15-20mmHg systolic,
illustrating the substantial potential for incremental benefit by adequate blood pressure
control across the 24 hour cycle in this population. In this study, the investigators wish
(i) to establish through repeated assessment, the stability of the non-dipping phenotype
(Phase 1), and (ii) to deeply phenotype non-dippers by using parameters assessing day/night
patterns, the chronobiome (Phase 2). To facilitate data collection over the course of the
study, the investigators use wearable devices and mobile phone applications.
myocardial infarction. Its prevalence in developed societies is increasing as they age, and
in less developed countries, as their populations assume aspects of the Western diet and
lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to
dip at night - is estimated to complicate ~40% of hypertensives and is associated with poor
outcomes. Randomized controlled trials have shown that a reduction of daytime systolic blood
pressure by as little as 5mmHg on average (towards a target of 140mmHg) translates into a
measurable clinical benefit. The peak nocturnal difference may be ~15-20mmHg systolic,
illustrating the substantial potential for incremental benefit by adequate blood pressure
control across the 24 hour cycle in this population. In this study, the investigators wish
(i) to establish through repeated assessment, the stability of the non-dipping phenotype
(Phase 1), and (ii) to deeply phenotype non-dippers by using parameters assessing day/night
patterns, the chronobiome (Phase 2). To facilitate data collection over the course of the
study, the investigators use wearable devices and mobile phone applications.
Phase 1: Inclusion Criteria (Stability of the non-dipping phenotype)
1. >18 years of age,
2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible,
for ABP measurements,
3. 24h mean wake SBP >145mmHg at baseline from 24hr-ABPM readings within the past 12
months,
4. Decline of <10% between mean day time and night time systolic pressures quantified per
24hr-ABPM within the past 6 months,
5. Own a smartphone.
Phase 1: Exclusion Criteria (Stability of the non-dipping phenotype)
1. Known history of severe psychiatric or cognitive conditions, for example mania,
schizophrenia, or mental retardation.
2. Shift work, defined as recurring work between 22:00-05:00,
3. History of clinically significant obstructive sleep apnea;
4. Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women,
5. Significant liver disease (>3x upper limit of normal),
6. Diabetes mellitus,
7. Transmeridian travel across ≥2 time zones in the month prior to ABP sessions,
8. Planned transmeridian travel across more than ≥2 time zones during the planned study
activities;
9. > 2 drinks of alcohol per day;
10. Use of illicit drugs which affect blood pressure;
11. Use of pacemaker or implantable Cardioverter Defibrillator, (ICD);
12. Bilateral mastectomy;
13. Hypotension, defined as 90/60 mmHg assessed during the screening visit from ≥ 3
in-office measurements initiated after 10 minutes in seated upright position with 5
minute intervals between measurements;
14. History of Raynaud's phenomenon;
15. Known allergy against natural latex rubber (contained in ABP bladder and tubing);
16. Nursing or pregnant females.
Phase 2: Inclusion Criteria (Deeply phenotyping non-dipping hypertensives)
Inclusion Cohort 1 (case): non-dipping hypertensives 'NDHT'
1. >18 years of age,
2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible,
for ABP measurements,
3. 24h mean wake SBP >145mmHg from 24hr-ABPM readings confirmed per data base query
within the past 12 months prior to enrollment into Phase 1 and across two subsequent
24hr-ABP sessions during Phase 1,
4. Decline of <10% between mean day time and night time systolic pressures from 24hr-ABPM
readings confirmed per data base query within the past 12 months prior to enrollment
into Phase 1 and across two subsequent 24hr-ABP sessions during Phase 1,
5. Own a smartphone.
Inclusion Cohort 2 (control): matched healthy normotensives 'NT'
1. >18 years of age,
2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible,
for ABP measurements,
3. Healthy (as assessed by health history, physical exam and screening lab work),
4. 24h mean wake SBP <130mmHg quantified per 24hr-ABPM,
5. Own a smartphone. 4.3.3 Inclusion Cohort 3 (control): matched dipping hypertensives
'DHT'
1) >18 years of age, 2) Upper arm with intact skin, i.e. without areas of breached or
injured skin visible, for ABP measurements,
1. 24h mean wake SBP >145mmHg from 24hr-ABPM readings,
2. Decline of >10% between mean day time and night time systolic pressures from 24hr-ABPM
readings,
3. Own a smartphone.
Phase 2 - Exclusion Criteria Cohorts 1-3
1. History of severe psychiatric illness or cognitive conditions, for example ( mania,
schizophrenia, or mental retardation;
2. Shift work, defined as recurring work between 22:00-05:00;
3. Clinically significant obstructive sleep apnea as assessed per WatchPAT device;
4. Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women;
5. Significant liver disease (>3x upper limit of normal);
6. Diabetes mellitus;
7. Past diagnosis of gastroesophageal reflux disease,
8. Transmeridian travel across ≥2 time zones in the two weeks before the 48hr deep
phenotype sessions;
9. Frequent transmeridian flyer (≥2 flights per month) across more than ≥2 time zones
during the 12 months of study activities;
10. Use of oral or intravenous antibiotics in the 6 months prior to enrollment;
11. Any contraindication listed below in the separate paragraph "Contraindications for the
use of CorTemp® Disposable Temperature Sensors";
12. Subjects, who have received an experimental drug, used an experimental medical device
within 30 days prior to screening, or who gave a blood donation of ≥ one pint within 8
weeks prior to screening;
13. > 2 drinks of alcohol per day;
14. Use of illicit drugs which affect blood pressure;
15. Nursing or pregnant (pregnancy will be repeatedly assessed at the beginning of each of
the four inpatient visits, i.e. prior to the start of blood draws);
16. Use of pacemaker or implantable Cardioverter Defibrillator, (ICD)
17. Bilateral mastectomy;
18. Hypotension, defined as 90/60 mmHg assessed during the screening visit from ≥ 3
in-office measurements initiated after 10 minutes in seated upright position with 5
minute intervals between measurements;
19. History of Raynaud's phenomenon;
20. Known allergy against natural latex rubber (contained in ABP bladder and tubing);
21. Subjects taking medication with alpha-blockers;
22. History of clinically significant arrhythmias;
23. Subjects with a history of being particularly susceptible to vomiting or nausea;
24. BMI ≥ 30;
25. History of any type of GI Surgery.
We found this trial at
1
site
Philadelphia, Pennsylvania 19104
Principal Investigator: Garret FitzGerald, MD
Phone: 215-662-4652
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