The STOP-HPV Trial 1: Communication Intervention

As highlighted by NCI, low HPV vaccination rates represent a major lost opportunity for
population-wide cancer prevention. Pediatric primary care office visits are the main site for
HPV vaccination, yet many missed opportunities (MOs) for vaccination occur in primary care
and contribute to low vaccination rates. MOs are office visits during which a patient is
eligible for a vaccine, but does not receive it. Many factors cause MOs - provider factors
(e.g., time-constrained visits, lack of communication skills, and giving vaccinations only at
preventive visits) and parent factors (e.g., vaccine hesitancy). This cluster randomized
clinical trial will test the effectiveness (and cost-effectiveness) of training providers in
HPV vaccine communication to reduce MOs and increase HPV vaccination rates. This training
will be done through online educational modules (sent via text or email), weekly mini lessons
and live office practice sessions.

Practice Inclusion Criteria:

- The practice provides HPV vaccination services to adolescents.

- The practice is part of Physician's Computer Company (PCC), Office Practicum (OP) or
(a) yet-to-be selected health system(s).

- The practice has had the same EHR system in place for a year or more (with special
consideration on a case by case basis if they are close to but not do not reach a
year).

- The practice agrees to not participate in other HPV-related QI projects or research
interventions during the study period (with special consideration on a case by case
basis).

Practice Exclusion Criteria:

- The practice plans to change EHR systems in the next three years.

- The practice participated in the last year, is currently engaged in, or plans to
participate in an office-based HPV-related quality improvement (QI) project or
research intervention during the study period (with special consideration on a case by
case basis).

- Estimated 20% or more of adolescents at the practice receive HPV vaccinations at
schools or health department clinics (given standard practice and published data, the
investigators expect that few to no practices will need to be excluded based on this
restriction).

Patient inclusion criteria:

-All patients of participating practices (intervention and comparison) aged 11-17 years who
have at least 1 visit to the practice within the past two years.

Patient exclusion criteria:

-None apart from age of patients (above).