Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage

Persistent headache is a significant medical issue that affects 20% of patients who survive
an aneurysmal subarachnoid hemorrhage (SAH). This headache may last years, severely affecting
quality of life. Laboratory evidence suggests that the persistent headache may be a result of
a maladaptive neuroinflammatory response to the hemorrhage injury that is more vigorous than
necessary. The goal of this study is to measure key immunomodulators in the blood and the
cerebrospinal fluid of these patients in order to determine the magnitude and dynamics of
their neuroinflammatory response. In addition, the investigators will collect and analyze
observational data about the success of medications to treat headache, with a specific focus
on the anti-inflammatory agent dexamethasone, in managing acute headache pain and preventing
the development of persistent headaches in patients after SAH.

Inclusion Criteria:

- 1. Patients with non-traumatic subarachnoid hemorrhage 2. Patients able to report pain
3. Treated with external ventricular drainage

Exclusion Criteria:

- 1. Pregnancy or lactation 2. Age < 18 years 3. Traumatic SAH 4. Patients unable to
report pain