The Influence of Oral Probiotics on the Microbiome and Lipidome
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/1/2018 |
| Start Date: | June 29, 2018 |
| End Date: | June 29, 2019 |
| Contact: | Iryna Rybak, BS |
| Email: | irybak@ucdavis.edu |
| Phone: | 916-734-1509 |
The purpose of this study is to measure oil production of the face, facial properties, and
gut bacteria in people being given oral probiotics. Probiotic supplements contain active
cultures of bacteria that are thought to be beneficial to human health.The investigators want
to find out if probiotics taken by mouth alter the bacteria in subject's gut and subject's
skin oil production compared to a placebo. This is a single blind study and subject may
receive a probiotic or a placebo for the first half of the study and a placebo or a probiotic
for the second half of the study. Subject will not know what was given to participants.
gut bacteria in people being given oral probiotics. Probiotic supplements contain active
cultures of bacteria that are thought to be beneficial to human health.The investigators want
to find out if probiotics taken by mouth alter the bacteria in subject's gut and subject's
skin oil production compared to a placebo. This is a single blind study and subject may
receive a probiotic or a placebo for the first half of the study and a placebo or a probiotic
for the second half of the study. Subject will not know what was given to participants.
Antibiotics are widely used within dermatology for the treatment of chronic skin conditions
such as acne, rosacea, and atopic dermatitis. Previous studies have shown that oral
probiotics may be beneficial for skin disesaes such as atopic dermatitis and acne, but a
mechanism for how the gut communicates to the skin remains elusive.
The balance between short chain fatty acids and long chain fatty acids has been proposed as
one factor in how bacteria in the gut are able to communicate with the rest of the body.
Studies in Dr. Sivamani's lab have shown that subjects with acne have a reduced level of
short chain fatty acids in their blood when compared to age-matched control (unpublished).
The aim of this study is to understand how oral probiotics may alter the gut microbiome and
if they can augment the short chain fatty acids in the blood lipidome. Ultimately, the
investigator's goal is to find suitable alternatives for the use of antibiotics in the
treatment of chronic skin conditions so that the amount of antibiotics that are in use can be
reduced.
such as acne, rosacea, and atopic dermatitis. Previous studies have shown that oral
probiotics may be beneficial for skin disesaes such as atopic dermatitis and acne, but a
mechanism for how the gut communicates to the skin remains elusive.
The balance between short chain fatty acids and long chain fatty acids has been proposed as
one factor in how bacteria in the gut are able to communicate with the rest of the body.
Studies in Dr. Sivamani's lab have shown that subjects with acne have a reduced level of
short chain fatty acids in their blood when compared to age-matched control (unpublished).
The aim of this study is to understand how oral probiotics may alter the gut microbiome and
if they can augment the short chain fatty acids in the blood lipidome. Ultimately, the
investigator's goal is to find suitable alternatives for the use of antibiotics in the
treatment of chronic skin conditions so that the amount of antibiotics that are in use can be
reduced.
Inclusion Criteria
• 18 years of age or older
Exclusion criteria
- Those on oral antibiotics within a month of initiating the study.
- Subjects must have no history of diabetes, known cardiovascular disease, known
immunocompromised condition, malignancy, kidney disease, or chronic steroid use.
- Subjects must have no history or diagnosis of gastrointestinal inflammatory diseases.
- Those with BMI higher than 30 kg/m²
- Those on topical medications to the face such as retinoids or antibiotics who are not
willing or medical unable (in the judgement of the investigator) to discontinue use
for two weeks prior to the study and for the duration of study participation.
- Those that have undergone a change in hormonally based therapies, such as but not
limited to oral contraceptive pills or progesterone based pills within the last two
months. Progesterone releasing IUDs are considered hormone releasing therapy.
- Use of medications that alter blood lipids, such as statins and anti-hyperlipidemic
medications
- Current tobacco smokers, OR those that have smoked tobacco over the past year, OR a 5
year-pack year history of smoking tobacco
- Pregnant women
- Prisoners
- Adults unable to consent
We found this trial at
1
site
Sacramento, California 95816
Principal Investigator: Raja K. Sivamani, MD
Phone: 916-734-1509
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