Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Endocrinology, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 2/10/2019 |
| Start Date: | April 2019 |
| End Date: | July 2020 |
| Contact: | Abhijit Naik, MD |
| Email: | abhinaik@med.umich.edu |
| Phone: | 734-763-0990 |
One possible reason that weight gain after transplant may interfere with new kidney function
is due to the enlargement of a kidney structure called the glomerulus.
The researchers believe that modest caloric intake reduction (CIR) early after kidney
transplantation can reduce the enlargement (hypertrophy) of the glomerulus associated with
kidney transplantation and may improve long term allograft survival, by reducing glomerular
hypertrophy mediated progressive glomerulosclerosis.
is due to the enlargement of a kidney structure called the glomerulus.
The researchers believe that modest caloric intake reduction (CIR) early after kidney
transplantation can reduce the enlargement (hypertrophy) of the glomerulus associated with
kidney transplantation and may improve long term allograft survival, by reducing glomerular
hypertrophy mediated progressive glomerulosclerosis.
Inclusion Criteria:
- Recipients of kidney transplants where a post perfusion biopsy is obtained
- Body Mass Index between 25-30 kg/m2 at the time of randomization
- Non-diabetic
- Have a smart phone or active internet connection at home
Exclusion Criteria:
- Patients on dual anti platelet agents or are on oral anti coagulation medication
- Patients who have had Bariatric Surgery
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