Long Pulse Versus Short Pulse Laser Dusting for Renal Stones
Status: | Not yet recruiting |
---|---|
Conditions: | Nephrology, Nephrology, Nephrology |
Therapuetic Areas: | Nephrology / Urology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 12/23/2018 |
Start Date: | May 2019 |
End Date: | December 2023 |
Contact: | Mary-Clare Day, RN |
Email: | mday@wakehealth.edu |
Phone: | 336-713-1343 |
The purpose of this research study is to compare how well two treatments work for removing
kidney stones. The two study groups include ureteroscopy with long/short pulse lithotripsy to
remove kidney stones. Both of these options are considered standard of care and are used
currently in surgery.
kidney stones. The two study groups include ureteroscopy with long/short pulse lithotripsy to
remove kidney stones. Both of these options are considered standard of care and are used
currently in surgery.
This study will compare two types of laser lithotripsy to see the pulse duration to determine
which settings are more effective. This is a randomized control trial with subjects
randomized to either long pulse or a short pulse group. Those subjects with a single
kidney/ureter stone measuring up to 20 mm will be eligible for the study. The procedures will
be performed using the standard of care instruments and techniques but the pulse type setting
in surgery will be constant. Some Holmium laser devices provide the option to modulate the
pulse duration. A longer laser pulse duration (700 μs or 1500 μs) as compared to a
traditional pulse duration (300 μs or 350 μs) has been demonstrated in vitro studies to
provide effective stone disintegration while reducing laser fiber tip degradation and stone
retropulsion. Both the long and the short setting can dust the stone and currently we
alternate in each procedure from one setting to the other and it is unclear which setting is
more effective. No changes to operative technique will be performed for subjects in the study
vs regular patients undergoing the same procedure. All subjects will be seen one week to one
month after surgery for stent removal and follow up.
which settings are more effective. This is a randomized control trial with subjects
randomized to either long pulse or a short pulse group. Those subjects with a single
kidney/ureter stone measuring up to 20 mm will be eligible for the study. The procedures will
be performed using the standard of care instruments and techniques but the pulse type setting
in surgery will be constant. Some Holmium laser devices provide the option to modulate the
pulse duration. A longer laser pulse duration (700 μs or 1500 μs) as compared to a
traditional pulse duration (300 μs or 350 μs) has been demonstrated in vitro studies to
provide effective stone disintegration while reducing laser fiber tip degradation and stone
retropulsion. Both the long and the short setting can dust the stone and currently we
alternate in each procedure from one setting to the other and it is unclear which setting is
more effective. No changes to operative technique will be performed for subjects in the study
vs regular patients undergoing the same procedure. All subjects will be seen one week to one
month after surgery for stent removal and follow up.
Inclusion Criteria:
- Kidney/ureter single stone between up to 2 cm
- Age over 18 years
- Two kidneys
Exclusion Criteria:
- Solitary Kidney
- Age under 18
- Pregnancy
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
Principal Investigator: Jorge Gutierrez-Aceves, MD
Phone: 336-713-1343
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