Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:8/3/2018
Start Date:July 2008
End Date:March 2011

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Phase IIIb Multicenter Study With a 12-week Double-blind, Placebo-controlled, Randomized Period Followed by an Open-label, Extension Phase Evaluating Safety/Efficacy of Certolizumab Pegol Given to Patients With Active Rheumatoid Arthritis.

This is a Phase IIIb multicenter study to evaluate the safety and efficacy of certolizumab
pegol (CZP) administered to patients with moderate-to-severe rheumatoid arthritis.

The treatment period starts with a 12-week, double-blind, placebo-controlled, randomized
period followed by an open-label extension phase. In the double-blind phase, eligible
patients are randomized (4:1 ratio) to receive either certolizumab pegol (CZP) or Placebo up
to and including Week 10. The randomization will be stratified according to the three
factors: concomitant use of methotrexate (MTX, Yes or No), prior anti-tumor necrosis factor
(anti-TNF) use (Yes or No), and disease duration categories (< 2 years or ≥ 2 years). From
Week 12 all patients remaining in the study receive open-label CZP for a minimum 16
additional weeks until CZP is commercially available.

Inclusion Criteria:

- Adult patient with established moderate to severe rheumatoid arthritis

Exclusion Criteria:

- All concomitant diseases or pathological conditions that could interfere and impact
the assessment of the study treatment

- Previous clinical trials and previous biological therapy that could interfere with the
results in the present clinical trials
We found this trial at
102
sites
Clinical Trial Facility in La Jolla California
La Jolla, California 92093
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
Clinical Trial Facility in Albany New York
Albany, New York 12205
?
mi
from
Albany, NY
Click here to add this to my saved trials
Clinical Trial Facility in Amarillo Texas
Amarillo, Texas
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Clinical Trial Facility in Austin Texas
Austin, Texas 78744
?
mi
from
Austin, TX
Click here to add this to my saved trials
Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Facility in Battle Creek Michigan
Battle Creek, Michigan
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Clinical Trial Facility in Boca Raton Florida
Boca Raton, Florida
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
?
mi
from
Boston, MA
Click here to add this to my saved trials
Clinical Trial Facility in Bronx New York
Bronx, New York
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Clinical Trial Facility in Chapel Hill North Carolina
Chapel Hill, North Carolina
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Clinical Trial Facility in Clarksburg West Virginia
Clarksburg, West Virginia 26301
?
mi
from
Clarksburg, WV
Click here to add this to my saved trials
Clinical Trial Facility in Coeur D'Alene Idaho
Coeur D'Alene, Idaho 83814
?
mi
from
Coeur D'Alene, ID
Click here to add this to my saved trials
Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
?
mi
from
Columbia, MD
Click here to add this to my saved trials
Clinical Trial Facility in Columbus Ohio
Columbus, Ohio 43214
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Clinical Trial Facility in Covington Louisiana
Covington, Louisiana 70433
?
mi
from
Covington, LA
Click here to add this to my saved trials
Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Clinical Trial Facility in Danbury Connecticut
Danbury, Connecticut 06810
?
mi
from
Danbury, CT
Click here to add this to my saved trials
Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Clinical Trial Facility in Delray Beach Florida
Delray Beach, Florida 33406
?
mi
from
Delray Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in Denver Colorado
Denver, Colorado
?
mi
from
Denver, CO
Click here to add this to my saved trials
Clinical Trial Facility in Duluth Minnesota
Duluth, Minnesota
?
mi
from
Duluth, MN
Click here to add this to my saved trials
Clinical Trial Facility in Edmonton Alberta
Edmonton, Alberta
?
mi
from
Edmonton,
Click here to add this to my saved trials
Clinical Trial Facility in Erie Pennsylvania
Erie, Pennsylvania 16502
?
mi
from
Erie, PA
Click here to add this to my saved trials
Clinical Trial Facility in Evansville Indiana
Evansville, Indiana 47713
?
mi
from
Evansville, IN
Click here to add this to my saved trials
Clinical Trial Facility in Fairfield Ohio
Fairfield, Ohio 45014
?
mi
from
Fairfield, OH
Click here to add this to my saved trials
Clinical Trial Facility in Fall River Massachusetts
Fall River, Massachusetts 02720
?
mi
from
Fall River, MA
Click here to add this to my saved trials
Clinical Trial Facility in Fort Worth Texas
Fort Worth, Texas
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Clinical Trial Facility in Frederick Maryland
Frederick, Maryland 21702
?
mi
from
Frederick, MD
Click here to add this to my saved trials
Clinical Trial Facility in Fullerton California
Fullerton, California 92835
?
mi
from
Fullerton, CA
Click here to add this to my saved trials
Clinical Trial Facility in Gainesville Florida
Gainesville, Florida 32610
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
Clinical Trial Facility in Glendale Wisconsin
Glendale, Wisconsin
?
mi
from
Glendale, WI
Click here to add this to my saved trials
Clinical Trial Facility in Hot Springs Arkansas
Hot Springs, Arkansas 71901
?
mi
from
Hot Springs, AR
Click here to add this to my saved trials
Clinical Trial Facility in Houston Texas
Houston, Texas
?
mi
from
Houston, TX
Click here to add this to my saved trials
Clinical Trial Facility in Idaho Falls Idaho
Idaho Falls, Idaho
?
mi
from
Idaho Falls, ID
Click here to add this to my saved trials
Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Clinical Trial Facility in Jackson Tennessee
Jackson, Tennessee 38305
?
mi
from
Jackson, TN
Click here to add this to my saved trials
Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Clinical Trial Facility in Kalamazoo Michigan
Kalamazoo, Michigan 49048
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
Clinical Trial Facility in Lake Charles Louisiana
Lake Charles, Louisiana 70601
?
mi
from
Lake Charles, LA
Click here to add this to my saved trials
Clinical Trial Facility in Lansing Michigan
Lansing, Michigan 48912
?
mi
from
Lansing, MI
Click here to add this to my saved trials
Clinical Trial Facility in Lewes Delaware
Lewes, Delaware
?
mi
from
Lewes, DE
Click here to add this to my saved trials
Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
Clinical Trial Facility in Los Angeles California
Los Angeles, California
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Clinical Trial Facility in Lubbock Texas
Lubbock, Texas 79410
?
mi
from
Lubbock, TX
Click here to add this to my saved trials
Clinical Trial Facility in Mayfield Ohio
Mayfield, Ohio 44143
?
mi
from
Mayfield, OH
Click here to add this to my saved trials
Clinical Trial Facility in Maywood Illinois
Maywood, Illinois 60153
?
mi
from
Maywood, IL
Click here to add this to my saved trials
Clinical Trial Facility in Milwaukee Wisconsin
Milwaukee, Wisconsin 53226
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Clinical Trial Facility in Monroe North Carolina
Monroe, North Carolina 28110
?
mi
from
Monroe, NC
Click here to add this to my saved trials
Clinical Trial Facility in Monroe Wisconsin
Monroe, Wisconsin 53566
?
mi
from
Monroe, WI
Click here to add this to my saved trials
Clinical Trial Facility in Montgomery Alabama
Montgomery, Alabama 36106
?
mi
from
Montgomery, AL
Click here to add this to my saved trials
Clinical Trial Facility in New Brunswick New Jersey
New Brunswick, New Jersey 08901
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
Clinical Trial Facility in New York New York
New York, New York 10032
?
mi
from
New York, NY
Click here to add this to my saved trials
Clinical Trial Facility in Newark Delaware
Newark, Delaware
?
mi
from
Newark, DE
Click here to add this to my saved trials
Clinical Trial Facility in Newport News Virginia
Newport News, Virginia 23601
?
mi
from
Newport News, VA
Click here to add this to my saved trials
Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Clinical Trial Facility in Orchard Park New York
Orchard Park, New York
?
mi
from
Orchard Park, NY
Click here to add this to my saved trials
Clinical Trial Facility in Orlando Florida
Orlando, Florida 32804
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Clinical Trial Facility in Palm Desert California
Palm Desert, California
?
mi
from
Palm Desert, CA
Click here to add this to my saved trials
Clinical Trial Facility in Peoria Illinois
Peoria, Illinois 61603
?
mi
from
Peoria, IL
Click here to add this to my saved trials
Clinical Trial Facility in Petoskey Michigan
Petoskey, Michigan 49770
?
mi
from
Petoskey, MI
Click here to add this to my saved trials
Clinical Trial Facility in Philadelphia Pennsylvania
Philadelphia, Pennsylvania
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Clinical Trial Facility in Phoenix Arizona
Phoenix, Arizona
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Clinical Trial Facility in Rochester Minnesota
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Clinical Trial Facility in Rochester New York
Rochester, New York
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Clinical Trial Facility in Rock Island Illinois
Rock Island, Illinois 61201
?
mi
from
Rock Island, IL
Click here to add this to my saved trials
Clinical Trial Facility in Roslyn New York
Roslyn, New York
?
mi
from
Roslyn, NY
Click here to add this to my saved trials
Clinical Trial Facility in Sacramento California
Sacramento, California 95825
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Clinical Trial Facility in Saint Louis Missouri
Saint Louis, Missouri 63110
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Clinical Trial Facility in Salt Lake City Utah
Salt Lake City, Utah
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Clinical Trial Facility in Santa Barbara California
Santa Barbara, California 93105
?
mi
from
Santa Barbara, CA
Click here to add this to my saved trials
Clinical Trial Facility in Santa Maria California
Santa Maria, California 93454
?
mi
from
Santa Maria, CA
Click here to add this to my saved trials
Clinical Trial Facility in Smithtown New York
Smithtown, New York 11787
?
mi
from
Smithtown, NY
Click here to add this to my saved trials
Clinical Trial Facility in South Miami Florida
South Miami, Florida 33143
?
mi
from
South Miami, FL
Click here to add this to my saved trials
Clinical Trial Facility in Spokane Washington
Spokane, Washington
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Clinical Trial Facility in Springfield Illinois
Springfield, Illinois 62704
?
mi
from
Springfield, IL
Click here to add this to my saved trials
Clinical Trial Facility in Sugar Land Texas
Sugar Land, Texas
?
mi
from
Sugar Land, TX
Click here to add this to my saved trials
Clinical Trial Facility in Syracuse New York
Syracuse, New York 13202
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
?
mi
from
Tacoma, WA
Click here to add this to my saved trials
Clinical Trial Facility in Tampa Florida
Tampa, Florida
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Clinical Trial Facility in Tavares Florida
Tavares, Florida
?
mi
from
Tavares, FL
Click here to add this to my saved trials
Clinical Trial Facility in Trumbull Connecticut
Trumbull, Connecticut 06611
?
mi
from
Trumbull, CT
Click here to add this to my saved trials
Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Clinical Trial Facility in Tustin California
Tustin, California 92780
?
mi
from
Tustin, CA
Click here to add this to my saved trials
Clinical Trial Facility in Voorhees New Jersey
Voorhees, New Jersey 08043
?
mi
from
Voorhees, NJ
Click here to add this to my saved trials
Clinical Trial Facility in Washington District of Columbia
Washington, District of Columbia
?
mi
from
Washington,
Click here to add this to my saved trials
Clinical Trial Facility in West Reading Pennsylvania
West Reading, Pennsylvania 19611
?
mi
from
West Reading, PA
Click here to add this to my saved trials
Clinical Trial Facility in Westlake Village California
Westlake Village, California 91361
?
mi
from
Westlake Village, CA
Click here to add this to my saved trials
Clinical Trial Facility in Wexford Pennsylvania
Wexford, Pennsylvania 15090
?
mi
from
Wexford, PA
Click here to add this to my saved trials
Clinical Trial Facility in Wheaton Maryland
Wheaton, Maryland 20902
?
mi
from
Wheaton, MD
Click here to add this to my saved trials
Clinical Trial Facility in Whittier California
Whittier, California 90602
?
mi
from
Whittier, CA
Click here to add this to my saved trials
Clinical Trial Facility in Wichita Kansas
Wichita, Kansas 67214
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Clinical Trial Facility in Wilmington North Carolina
Wilmington, North Carolina 28401
?
mi
from
Wilmington, NC
Click here to add this to my saved trials