Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia



Status:Active, not recruiting
Conditions:Blood Cancer, Blood Cancer, Infectious Disease, Hematology, Hematology
Therapuetic Areas:Hematology, Immunology / Infectious Diseases, Oncology
Healthy:No
Age Range:18 - Any
Updated:8/3/2018
Start Date:August 2016
End Date:August 2018

Use our guide to learn which trials are right for you!

Shotgun Sequencing for Etiologic Diagnosis of Febrile Neutropenia

This research trial studies the shotgun sequencing of blood samples in diagnosing febrile
neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients
with acute myeloid leukemia in the laboratory may help identify pathogens and accurately
diagnose infections such as febrile neutropenia.

PRIMARY OBJECTIVES:

I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care
diagnostics in the detection of pathogens in patients with febrile neutropenia.

SECONDARY OBJECTIVES:

I. To establish a microbiological diagnosis with known or unknown pathogens in patients in
whom standard care failed to yield a pathogenic diagnosis.

OUTLINE:

Patients undergo collection of blood samples before and during the episode of febrile
neutropenia for up to 6 weeks.

Inclusion Criteria:

- Patients with febrile neutropenia

- A primary diagnosis of acute myeloid leukemia (AML)

Exclusion Criteria:

- Prior history of febrile neutropenia
We found this trial at
1
site
Palo Alto, California 94304
?
mi
from
Palo Alto, CA
Click here to add this to my saved trials