Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia
Status: | Active, not recruiting |
---|---|
Conditions: | Blood Cancer, Blood Cancer, Infectious Disease, Hematology, Hematology |
Therapuetic Areas: | Hematology, Immunology / Infectious Diseases, Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 8/3/2018 |
Start Date: | August 2016 |
End Date: | August 2018 |
Shotgun Sequencing for Etiologic Diagnosis of Febrile Neutropenia
This research trial studies the shotgun sequencing of blood samples in diagnosing febrile
neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients
with acute myeloid leukemia in the laboratory may help identify pathogens and accurately
diagnose infections such as febrile neutropenia.
neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients
with acute myeloid leukemia in the laboratory may help identify pathogens and accurately
diagnose infections such as febrile neutropenia.
PRIMARY OBJECTIVES:
I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care
diagnostics in the detection of pathogens in patients with febrile neutropenia.
SECONDARY OBJECTIVES:
I. To establish a microbiological diagnosis with known or unknown pathogens in patients in
whom standard care failed to yield a pathogenic diagnosis.
OUTLINE:
Patients undergo collection of blood samples before and during the episode of febrile
neutropenia for up to 6 weeks.
I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care
diagnostics in the detection of pathogens in patients with febrile neutropenia.
SECONDARY OBJECTIVES:
I. To establish a microbiological diagnosis with known or unknown pathogens in patients in
whom standard care failed to yield a pathogenic diagnosis.
OUTLINE:
Patients undergo collection of blood samples before and during the episode of febrile
neutropenia for up to 6 weeks.
Inclusion Criteria:
- Patients with febrile neutropenia
- A primary diagnosis of acute myeloid leukemia (AML)
Exclusion Criteria:
- Prior history of febrile neutropenia
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