Composition and Collection Feasibility of Gut Microbiota in Children With and Without Obesity
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 5 - 12 |
| Updated: | 11/16/2018 |
| Start Date: | March 7, 2017 |
| End Date: | December 31, 2018 |
Adults with obesity have an imbalance of bacteria in their intestines which may contribute to
weight gain and diseases related to obesity. Restoring the balance of these bacteria (the
"microbiota") could help reduce weight and related diseases. However, little is known about
this imbalance in children with obesity. This research study will map out the compositions of
the gut microbiota of children and compare them with those of children who have healthy
weights and different degrees of obesity. This project will also measure the amounts of fatty
acids in the stools which are an indication of how efficiently the intestines absorb calories
from food. If an imbalance is detected in children with obesity, then this information can
help researchers test ways to restore the gut microbiota with hopes of reducing weight and
some of its related health problems.
weight gain and diseases related to obesity. Restoring the balance of these bacteria (the
"microbiota") could help reduce weight and related diseases. However, little is known about
this imbalance in children with obesity. This research study will map out the compositions of
the gut microbiota of children and compare them with those of children who have healthy
weights and different degrees of obesity. This project will also measure the amounts of fatty
acids in the stools which are an indication of how efficiently the intestines absorb calories
from food. If an imbalance is detected in children with obesity, then this information can
help researchers test ways to restore the gut microbiota with hopes of reducing weight and
some of its related health problems.
Inclusion Criteria:
1) patients aged 5-12 years
Exclusion Criteria:
1. patient who have received either oral or parenteral antibiotics in the last 3 months
2. patients who have a diagnosed immunodeficiency
3. patients who are on medications that modulate the immune system including systemic
prednisone and biologics
4. patients who have a gastrointestinal condition which is known to alter the gut flora
such as inflammatory bowel disease, chronic diarrhea, celiac disease and eosinophilic
gastroenteritis diseases
5. patients who have taken proton pump inhibitors in the last 3 months
6. patients who have taken probiotics in the last 6 months.
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