EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 3/9/2019 |
| Start Date: | November 2019 |
| End Date: | November 2021 |
| Contact: | Edlyn Zhang |
| Email: | erzhang@mgh.harvard.edu |
| Phone: | 617-726-3540 |
Electroencephalogram Study of Intravenous Methylphenidate-Induced Emergence From Propofol Sedation
The investigators are performing this research study to find out if intravenous (IV)
methylphenidate (commonly known as Ritalin) can help people recover faster from propofol
sedation. The investigators also want to know how IV methylphenidate acts in the brain and
whether IV methylphenidate is safe to take with an anesthetic (a drug or agent used to
decrease or eliminate the feeling of pain by causing unconsciousness) without causing too
many side effects. The brain's electrical activity will be studied and recorded using a
machine called an electroencephalogram (EEG).
methylphenidate (commonly known as Ritalin) can help people recover faster from propofol
sedation. The investigators also want to know how IV methylphenidate acts in the brain and
whether IV methylphenidate is safe to take with an anesthetic (a drug or agent used to
decrease or eliminate the feeling of pain by causing unconsciousness) without causing too
many side effects. The brain's electrical activity will be studied and recorded using a
machine called an electroencephalogram (EEG).
During this research study, participants will receive propofol, and propofol and IV
methylphenidate together, at a high enough dose to achieve unconsciousness (make study
participants "fall asleep"). During one visit participants will receive propofol and a saline
placebo; during another visit participants will be given both propofol and IV methylphenidate
together. The investigators will record EEG the entire time, The investigators will also ask
some questions related to cognitive function.
methylphenidate together, at a high enough dose to achieve unconsciousness (make study
participants "fall asleep"). During one visit participants will receive propofol and a saline
placebo; during another visit participants will be given both propofol and IV methylphenidate
together. The investigators will record EEG the entire time, The investigators will also ask
some questions related to cognitive function.
Inclusion Criteria:
- Between the ages of 18 to 45
- Normal body weight and habitus, BMI ≤ 30
- Non-smoker
- No history of taking stimulants
- American Society of Anesthesiologists (ASA) physical status classification P1
Exclusion Criteria:
• Chronic health conditions
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