Vitamin C & Exercise Induced Bronchoconstriction (EIB)
| Status: | Recruiting |
|---|---|
| Conditions: | Asthma, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/3/2018 |
| Start Date: | July 1, 2018 |
| End Date: | May 1, 2019 |
| Contact: | Dave Burnett, PhD, RRT, AE-C |
| Email: | dburnett@kumc.edu |
| Phone: | 913-588-9499 |
Vitamin C Supplementation to Improve EIB in College Student-Athletes
The purpose of this research is to assess the association between diet and pulmonary function
during standardized EIB testing. Determine the effect of Vitamin C supplementation on airway
inflammatory markers and bronchoconstriction after a standardized EIB test compared to usual
diet and placebo control.
during standardized EIB testing. Determine the effect of Vitamin C supplementation on airway
inflammatory markers and bronchoconstriction after a standardized EIB test compared to usual
diet and placebo control.
This study will use a double-blind, randomized, cross-over design with subjects serving as
their own controls. This study will be conducted over a consecutive five-week period.
All subjects will be asked to discontinue taking their short- and long-acting beta-agonist
medication 12 and 24 hours respectively prior to data collection. Also, all subjects will be
asked to refrain from caffeine, physical activity, and NSAID use 24 hours prior to testing.
In addition all subjects will be asked to abstain from taking any vitamin supplement during
the course of the study.
their own controls. This study will be conducted over a consecutive five-week period.
All subjects will be asked to discontinue taking their short- and long-acting beta-agonist
medication 12 and 24 hours respectively prior to data collection. Also, all subjects will be
asked to refrain from caffeine, physical activity, and NSAID use 24 hours prior to testing.
In addition all subjects will be asked to abstain from taking any vitamin supplement during
the course of the study.
Inclusion Criteria:
- Student or student-athlete who has tested positive for EIB
- Able to communicate in English
Exclusion Criteria:
- Forced expiratory volume in 1 second (FEV1) < 70% of predicted, cardiac history,
- Current respiratory infection
- > 10 pack year history of smoking
- Pregnancy.
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