Quality of Life in Female Breast Cancer Survivors and Their Spouse, Partner, or Acquaintance

OBJECTIVES:

- Compare the quality of life (physical functioning, psychological functioning, social
functioning, and spiritual functioning) of female breast cancer survivors who were age
45 or younger at the time of diagnosis with the quality of life of female breast cancer
survivors who were age 55 to 70 at time of diagnosis (considering type of surgical
treatment [lumpectomy vs mastectomy], hormonal treatments, and time since diagnosis as
covariates) and age-matched (to the younger group) females with no history of breast
cancer.

- Compare the quality of life (physical functioning, psychological functioning, social
functioning, and spiritual functioning) of partners of breast cancer survivors who were
age 45 or younger at time of diagnosis with the quality of life of partners of breast
cancer survivors who were age 55 to 70 at diagnosis and partners of age-matched (to the
younger group) females with no history of breast cancer.

- Test and compare quality of life models that identify the variables that mediate between
antecedent variables of personal characteristics, diagnostic and treatment
characteristics, and quality of life outcomes in order to determine where interventions
to improve quality of life should be targeted.

- Explore the relationship of partner antecedent, mediating, and outcome variables as
predictors or mediators of outcome variables for breast cancer survivors.

OUTLINE: This is a multicenter study.

Patients, spouse or partner of patients, age-matched acquaintances of patients, and partner
of acquaintances complete questionnaires over 60-90 minutes about personal characteristics,
self-efficacy, coping, social support, health care provider communication, physical,
psychological, social, and spiritual functioning, and quality of life. After completing the
study questionnaires, patients and age-matched acquaintances of patients are interviewed via
telephone over 30 minutes for cognitive function assessment. A random subset of patients and
spouses/partners of patients are interviewed via telephone over 45-60 minutes, using
data-generating and open-ended questions, regarding physical functioning, sexual and
reproductive issues, psychological issues, social impact, and methods used to deal with
breast cancer survivor concerns.

Disease and treatment characteristics of patients are obtained from medical records.

PROJECTED ACCRUAL: A total of 2,697 patients, spouse or partner of patients, age-matched
female acquaintances of patients, and partner of acquaintances will be accrued for this
study.

DISEASE CHARACTERISTICS:

- Patient

- Female breast cancer survivor with age at initial diagnosis in 1 of the following
ranges:

- 18 to 45

- 55 to 78

- Must have enrolled and participated in ECOG study CLB-9741, E-1199, or E-2197

- Must have received chemotherapy at least 3 years, but no more than 8 years prior
to this study entry

- Disease free at the time of this study entry

- Spouse or partner of the patient, age-matched female acquaintances of the patient (in
the younger patient group), or partner of acquaintances

- Spouse or partner of the patient may be either gender

- Age-matched female acquaintance is defined as within 5 years of age difference of
the patient in younger group (18-45 years of age)

- With a similar level of education and race of the patient

- Not a personal friend of the patient

- No history of breast cancer

PATIENT CHARACTERISTICS:

- Must reside in the continental U.S. and speak English (for patients)

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics