Study of Time-restricted Eating on Weight Loss.
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 64 |
| Updated: | 10/13/2018 |
| Start Date: | July 30, 2018 |
| End Date: | August 30, 2019 |
| Contact: | Dylan A Lowe, BS |
| Email: | Dylan.Lowe@ucsf.edu |
| Phone: | 5703509378 |
Study of Time-restricted Eating on Weight Loss. A Randomized Controlled Trial of the Effects of Time-restricted Eating on Weight Loss in Obese Subjects.
This is a randomized controlled trial studying the effects of time-restricted feeding (TRF)
on weight loss in obese humans. Obesity is the number one risk factor for type 2 Diabetes
Mellitus (T2DM), and numerous studies demonstrate that weight loss is an effective strategy
to prevent T2DM and improve the metabolic health of people diagnosed with T2DM.
Unfortunately, classical calorie restriction diets often fail to produce long-term weight
loss due to low compliance, reduced resting metabolic rate (RMR), and other factors.
Therefore, novel dieting techniques must be explored in order to successfully treat obesity
and prevent T2DM. Studies in mice provide compelling evidence that feeding/fasting cycles can
be altered to produce beneficial effects on weight loss and metabolic health markers in the
absence of calorie restriction. Limited research in human subjects suggests that this feeding
paradigm may translate to human health as well, however, more research needs to be done in
order to confirm this hypothesis. This study will determine if TRE can lead to weight loss in
obese human subjects. Secondary outcomes include changes in body composition, HOMA-IR,
hormonal and biochemical serum markers, RMR, and total energy expenditure (TEE).
on weight loss in obese humans. Obesity is the number one risk factor for type 2 Diabetes
Mellitus (T2DM), and numerous studies demonstrate that weight loss is an effective strategy
to prevent T2DM and improve the metabolic health of people diagnosed with T2DM.
Unfortunately, classical calorie restriction diets often fail to produce long-term weight
loss due to low compliance, reduced resting metabolic rate (RMR), and other factors.
Therefore, novel dieting techniques must be explored in order to successfully treat obesity
and prevent T2DM. Studies in mice provide compelling evidence that feeding/fasting cycles can
be altered to produce beneficial effects on weight loss and metabolic health markers in the
absence of calorie restriction. Limited research in human subjects suggests that this feeding
paradigm may translate to human health as well, however, more research needs to be done in
order to confirm this hypothesis. This study will determine if TRE can lead to weight loss in
obese human subjects. Secondary outcomes include changes in body composition, HOMA-IR,
hormonal and biochemical serum markers, RMR, and total energy expenditure (TEE).
Inclusion Criteria:
- BMI between 30-40 kg/m2
- Participants must regularly consume breakfast (at least 5 days per week)
- Must speak, read, and comprehend English
- Access to reliable internet and/or wifi
- Must have a valid email address and phone number
- Must have a cellular phone with data plan
Exclusion Criteria:
- HIV or immunocompromised
- Current or past cancer diagnosis
- Pregnant, breastfeeding, or planned pregnancy in next 6 months
- Beginning or ending hormonal contraception in next 6 months
- Current diagnosis of type or type 2 diabetes
- Currently taking glucose-lowering drugs, statins, or oral steroids
- History of gastric bypass surgery or any other weight-loss surgery
- History of anorexia or bulimia
- Frequent travel across time zones or unusual work hours
- Unable to fast for prolonged periods due to medical condition
- Unable to stand for several minutes without aid
- Cannot lie down on cushioned table for 30 minutes
- No internal metal artifacts that would alter body composition
- Unable to travel to UCSF for in-person testing
- Requires translator services
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