A Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With Autism Spectrum Disorder (ASD)

Inclusion Criteria for All Participants

- Males and females

- Availability of a parent or other reliable caregiver. The same person must agree to
accompany the participant to all clinic visits and provide information about the
participant's behavior and symptoms

Inclusion Criteria for Participants with Autism Spectrum Disorders (ASD)(Diagnostic
evaluations will be completed at study site by research staff and supervised by a licensed
psychologist)

- Age: 5-45 years

- Diagnosis of ASD based on the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5), and the Autism Diagnostic Observation Schedule (ADOS-2).

- Children's Yale-Brown Obsessive Compulsive Scale modified for ASD (CY-BOCS-ASD) total
score of at least 12

- Clinical Global Impression-Severity (CGI-S) scale of at least 4 about participant's
current autism severity

- Intelligence quotient (IQ) score of 50 or above as assessed by the Abbreviated
Intelligence Quotient (ABIQ) SB5 scale

- All medications and treatments are expected to be stable for the duration of the study

Inclusion Criteria for Healthy Volunteers

-Children ages 5-12 years

Exclusion Criteria for All Participants

- Participation in an in investigational drug or device study within 4 weeks or 5 times
the half-life of the investigational molecule prior to screening, and participant is
not expected to enroll in any other trial during the study

- Co-occurring disease, condition, or treatment that might interfere with the conduct of
the study or pose an unacceptable risk to the participant

- Unstable or uncontrolled clinically significant psychiatric and/or neurological
disorder that may interfere with study objectives

Exclusion Criteria for Participants with ASD -Known "syndromic" ASD (e.g. Fragile X
syndrome, Angelman syndrome, Prader-Willi, Rett's syndrome, tuberous sclerosis, Dup15q
syndrome) History of alcohol misuse and/or illicit drug use during the last 12 months of
the study

Exclusion Criteria for Healthy Volunteers

-Healthy children with a brother or sister with ASD (first-degree sibling)