Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue



Status:Not yet recruiting
Healthy:No
Age Range:12 - Any
Updated:2/9/2019
Start Date:April 1, 2019
End Date:April 1, 2019
Contact:Rosie M Turner, MS
Email:rmturner@uab.edu
Phone:205-975-4906

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this investigation is to assess the use of a novel scaffold (an FDA-approved
collagen-hydroxyapatite material called Syn-Oss) for regeneration of pulp tissues versus the
use of a traditional scaffold (blood clot).

Regeneration of pulp tissues in teeth with immature roots is a new concept based on
historical limited success using calcium hydroxide dressings placed into debrided pulp
spaces. Obtaining stem cells from the apical papilla (SCAP cells), which are present at the
base of all teeth, but are most accessible in teeth with immature apices, greatly enhances
clinical success. Current therapies lack ideal messenger chemicals and scaffolds to optimize
results.

Inclusion Criteria:

1. Single root canal space apparent on a standard dental periapical radiograph

2. Immature tooth apex width at least 1.1mm in diameter as measured from the radiograph

3. No history of antibiotic drug allergy

4. Necrotic pulp as demonstrated by coronal discoloration.

5. Periapical radiolucency

6. Negative pulp sensibility tests

7. Other standard clinical means of assessing pulp vitality status

Exclusion Criteria:

1. Any patients having an American Association of Anesthesiologists 4 health classification
will be excluded.
We found this trial at
1
site
University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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mi
from
Birmingham, AL
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