Sodium Nitrate to Improve Blood Flow
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 15 - 55 |
| Updated: | 8/8/2018 |
| Start Date: | October 2013 |
| End Date: | December 2014 |
Investigators recently showed that tadalafil restores functional sympatholysis in patients
with Becker muscular dystrophy (BMD). If tadalafil restores functional sympatholysis in BMD
via the NO-cyclic guanosine monophosphate pathway, then functional sympatholysis should also
be restored by sodium nitrite— which is an indirect nitric oxide donor.
with Becker muscular dystrophy (BMD). If tadalafil restores functional sympatholysis in BMD
via the NO-cyclic guanosine monophosphate pathway, then functional sympatholysis should also
be restored by sodium nitrite— which is an indirect nitric oxide donor.
Inclusion Criteria:
- Becker muscular dystrophy
- age 15-55 years of age
- ambulatory
Exclusion Criteria:
- hypertension, diabetes, or heart failure by standard clinical criteria
- elevated brain natriuretic peptide level (>100 pg/ml)
- Left ventricular ejection fraction < 50%
- cardiac rhythm disorder, specifically: rhythm other than sinus, supraventricular
tachycardia, atrial fibrillation, ventricular tachycardia, heart block
- continuous ventilatory support
- liver disease
- renal impairment
- history of asthma or bronchospasm
- use of any medications other than common supplements
- unable to perform handgrip exercise
We found this trial at
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Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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