Mupirocin-Iodophor ICU Decolonization Swap Out Trial



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:8/8/2018
Start Date:May 1, 2017
End Date:December 2023
Contact:Katie Haffenreffer
Email:Katie_Haffenreffer@hphc.org
Phone:617-867-4807

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Trial Summary
Trial Overview
Inclusion Criteria

Cluster-randomized Non-inferiority Trial Comparing Mupirocin vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the
non-inferiority of two decolonization regimens:

Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the
context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with
iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that
enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that
have been randomized.


Inclusion Criteria:

- Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;

- Note: Unit of randomization is the hospital, but the participants are hospital adult
ICUs

- All patients within adult ICUs are included, including rare patients <18 years and
>=12 years.

Exclusion Criteria:

- Exclusion criteria includes ICUs with an average length of stay of less than 2 days;

- HCA hospitals that are not able to transfer or merge data into the centralized data
warehouse for the baseline and intervention periods of the study are also excluded.
We found this trial at
137
sites
John Randolph Medical Center
Hopewell, Virginia 23860
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Medical City Dallas Hospital
7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
Medical City Dallas Hospital If you have concerns for your health, that of a family...
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Presbyterian - St. Luke's Medical Center
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
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Rapides Regional Medical Center
211 4th Street
Alexandria, Louisiana 71301
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Alexandria, LA
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Medical Center of Arlington
Arlington, Texas 76015
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JFK Medical Center
Atlantis, Florida 33462
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Atlantis, FL
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Doctors Hospital of Augusta
Augusta, Georgia 30909
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Medical Center of Aurora
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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South Austin Hospital
Austin, Texas 78745
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North Austin Medical Center
Austin, Texas 78758
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Aventura Hospital
Aventura, Florida 33180
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Aventura, FL
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Belton Regional Medical Center
Belton, Missouri 64012
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Belton, MO
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LewisGale Hospital - Montgomery
Blacksburg, Virginia 24060
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Blacksburg, VA
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Lakeview Hospital
Bountiful, Utah 84010
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Bountiful, UT
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Greenview Regional Hospital
Bowling Green, Kentucky 42104
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Bowling Green, KY
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Blake Medical Center
Bradenton, Florida 34209
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Bradenton, FL
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Brandon Regional
Brandon, Florida 33511
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Brandon, FL
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Oak Hill Hospital
Brooksville, Florida 34613
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Valley Regional Medical Center
Brownsville, Texas 78526
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West Valley Medical Center
Caldwell, Idaho 83605
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Cartersville Medical Center
Cartersville, Georgia 30120
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Trident Regional Medical Center
Charleston, South Carolina 29406
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Parkridge Medical Center
Chattanooga, Tennessee 37404
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Parkridge East Hospital
Chattanooga, Tennessee 37412
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Conroe Regional Medical Center
Conroe, Texas 77304
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Corpus Christi Medical Center - Doctor's
Corpus Christi, Texas 78411
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Corpus Christi, TX
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Corpus Christi Medical Center - The Heart Hospital
Corpus Christi, Texas 78412
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Lakeview Regional Medical Center
Covington, Louisiana 70433
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Covington, LA
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Denton Regional Medical Center
Denton, Texas 76210
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Swedish Medical Center
Denver, Colorado 80110
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Sky Ridge Medical Center
Denver, Colorado 80124
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Rose Medical Center
4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
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Parkland Medical Center
Derry, New Hampshire 03038
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Fairview Park
Dublin, Georgia 31021
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Las Palmas Medical Center
El Paso, Texas 79902
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El Paso, TX
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Del Sol Medical Center
El Paso, Texas 79925
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Englewood Community Hospital
Englewood, Florida 34223
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Englewood, FL
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Lawnwood Regional Medical Center
Fort Pierce, Florida 34950
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Fort Pierce, FL
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Fort Walton Medical Center
Fort Walton Beach, Florida 32547
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Fort Walton Beach, FL
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Plaza Medical Center of Fort Worth
Fort Worth, Texas 76104
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Fort Worth, TX
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Spotsylvania Regional Medical Center
Fredericksburg, Pennsylvania 22408
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Fredericksburg, PA
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North Florida Regional Medical Center
Gainesville, Florida 32605
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Garden Park Medical Center
Gulfport, Mississippi 39503
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Gulfport, MS
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Hendersonville Medical Center
Hendersonville, Tennessee 37075
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Hendersonville, TN
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Summit Medical Center
Hermitage, Tennessee 37076
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Hermitage, TN
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East Houston Regional Medical Center
Houston, Texas 77015
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Houston, TX
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West Houston Medical Center
Houston, Texas 77082
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Houston, TX
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Regional Medical Center Bayonet Point
14000 Fivay Road
Hudson, Florida 34667
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Hudson, FL
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Eastern Idaho Regional
Idaho Falls, Idaho 83404
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Centerpoint Medical Center LLC
Independence, Missouri 64057
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Independence, MO
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Las Colinas Medical Center
Irving, Texas 75039
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Memorial Hospital Jacksonville
Jacksonville, Florida 32216
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Research Medical Center
2316 E Meyer Blvd
Kansas City, Missouri 64132
(816) 276-4000
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
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Kingwood Medical Center
Kingwood, Texas
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Osceola Regional Med Ctr
Kissimmee, Florida 34741
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Kissimmee, FL
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Poinciana Medical Center
Kissimmee, Florida 34758
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Lake City Medical Center
Lake City, Florida 32055
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Lake City, FL
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Largo Medical Center
Largo, Florida 33770
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Largo, FL
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Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
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Las Vegas, NV
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Mountainview Hospital - Vegas
Las Vegas, Nevada 89128
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Southern Hills Hospital - Vegas
Las Vegas, Nevada 89148
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Lee's Summit Medical Center
Lee's Summit, Missouri 64063
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Lee's Summit, MO
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Medical Center of Lewisville
Lewisville, Texas 75057
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Lewisville, TX
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LewisGale Hospital-Alleghany
Low Moor, Virginia 24457
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Low Moor, VA
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Palms West Hospital
13001 Southern Boulevard
Loxahatchee Groves, Florida 33470
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Loxahatchee Groves, FL
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Coliseum Medical Centers - Main
Macon, Georgia 31217
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Macon, GA
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Coliseum Medical Centers - Northside
Macon, Georgia 31217
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Macon, GA
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Northwest Medical Center
Margate, Florida 33063
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Margate, FL
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Rio Grande Regional Hospital
McAllen, Texas 78503
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McAllen, TX
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Medical Center of McKinney
McKinney, Texas 75069
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McKinney, TX
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Mercy Hospital
Miami, Florida 33133
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Kendall Regional Medical Center
Miami, Florida 33175
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Miami, FL
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Grand Strand Regional Medical Center
Myrtle Beach, South Carolina 29572
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Myrtle Beach, SC
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Stonecrest Medical Center
Nashville, Tennessee 37167
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Centennial Medical Center
Nashville, Tennessee 37203
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Skyline Medical Center
Nashville, Tennessee 37207
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Southern Hills Medical Center
Nashville, Tennessee 37211
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
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New Orleans, LA
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Twin Cities Hospital
Niceville, Florida 32578
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Niceville, FL
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North Hills Hospital
North Richland Hills, Texas 76180
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North Richland Hills, TX
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Ocala Regional Medical Center
Ocala, Florida 34480
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Ocala, FL
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West Marion Community Hospital
Ocala, Florida 34474
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Ocala, FL
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Ogden Regional Medical Center
5475 South 500 East
Ogden, Utah 84405
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Ogden, UT
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Raulerson Hospital
Okeechobee, Florida 34972
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Okeechobee, FL
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Orange Park Medical Center
Orange Park, Florida 32073
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Orange Park, FL
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Timpanogos Regional Medical Center
750 West 800 North
Orem, Utah 84057
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Orem, UT
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Menorah Medical Center
5721 W 119th St
Overland Park, Kansas 66209
(913) 498-6000
Menorah Medical Center Menorah Medical Center (MMC), a full-service, acute care hospital located on the...
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Overland Park Regional Medical Center
Overland Park, Kansas 66215
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Gulf Coast Medical Center
Panama City, Florida 32405
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Panama City, FL
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Bayshore Medical Center
Pasadena, Texas 77504
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Pasadena, TX
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Mountain View Hospital - Utah
Payson, Utah 84651
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Payson, UT
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West Florida Hospital
Pensacola, Florida 32514
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Pensacola, FL
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The Medical Center of Plano
Plano, Texas 75075
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Plano, TX
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Plantation General Hospital
Plantation, Florida 33317
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Plantation, FL
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Westside Regional Medical Center
Plantation, Florida 33324
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Plantation, FL
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Fawcett Memorial Hospital
Port Charlotte, Florida 33952
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Port Charlotte, FL
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St Lucie Medical Center
Port Saint Lucie, Florida 34952
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Port Saint Lucie, FL
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Portsmouth Regional Hospital
Portsmouth, New Hampshire 03801
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Portsmouth, NH
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LewisGale Hospital - Pulaski
Pulaski, Virginia 24301
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Pulaski, VA
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Reston Hospital
Reston, Virginia 20190
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Reston, VA
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Henrico Doctors' Hospital - Retreat Campus
Richmond, Virginia 23220
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