Functional MRI Study in Healthy Children Engaged in Aggressive Behaviors

The PSAP is a behavioral aggression test used to evaluate behavioral response related to
impulsive aggression. The task will be combined with functional MRI to establish a reliable
BOLD signal during testing in developing healthy subjects (8-12 years old) and, to determine
the feasibility to perform the task.

Additionally, the levels of neurotransmitters Glutamate and GABA will be measured using
magnetic resonance spectroscopy (MRS).

Inclusion Criteria:

Healthy male or female subjects, aged 8-12 years (inclusive) at the time of screening.

Exclusion Criteria:

1. Current history of developmental, psychiatric, or neurologic disorder, including
seizures (except for uncomplicated brief febrile seizures), tumor, severe head
injury/traumatic brain injury, stroke, lesion, or disease.

2. Known or suspected intelligence quotient (IQ) <70, diagnosis of mental retardation or
cerebral palsy or speech/language disorder and history of implanted brain stimulator,
vagal nerve stimulator, ventriculoperitoneal shunt, cardiac pacemaker, orthodontic
braces, or implanted medication port.

3. Visual and hearing (≥25 dB) impairment.

4. Pre-existing medical or psychological conditions that preclude being in the MRI
scanner (e.g., claustrophobia, morbid obesity, or marked anxiety about the procedure).