Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 29 |
| Updated: | 8/8/2018 |
| Start Date: | January 2015 |
| End Date: | December 2018 |
| Contact: | Mohamad Rashid, CCRC |
| Email: | MOHAMAD.RASHID@CSHS.ORG |
| Phone: | 4243152501 |
Effects of Hookah Smoking on Vascular Regulation: Novel Insight Into Endothelial Function
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on
blood vessel function. Hookah smoking has been shown to immediately increase blood pressure
and heart rate which could result in damage in the inner lining of the body's blood vessels.
blood vessel function. Hookah smoking has been shown to immediately increase blood pressure
and heart rate which could result in damage in the inner lining of the body's blood vessels.
The investigators will measure acute endothelial and vascular changes before and after a
30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the
acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by
brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on
micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial
tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and
aortic pressure waveform measured by pulse tonometry.
30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the
acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by
brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on
micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial
tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and
aortic pressure waveform measured by pulse tonometry.
Inclusion Criteria:
- 18 to 29 years of age
- Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12
months
- Have not smoked cigarettes within the past 12 months
Exclusion Criteria:
- History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
- Exhaled carbon monoxide level >10 ppm
- BP < 140/90 mmHg
- BMI <18.5 or > 30 kg•m2
- Resting heart rate > 100 beats/min
- Taking prescription medication
- History of illicit drug use
- Pregnant
We found this trial at
1
site
8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Phone: 310-248-7641
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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