Studying Biomarkers in Samples From Younger Patients With Kidney Cancer



Status:Withdrawn
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:8/9/2018
Start Date:August 22, 2012

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Trial Summary
Trial Overview
Inclusion Criteria

Focal Adhesion Kinase Expression in Pediatric Renal Tumors

This laboratory study is looking into biomarkers in samples from younger patients with kidney
cancer. Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
It may also help doctors find better ways to treat cancer.

PRIMARY OBJECTIVES:

I. To determine whether focal adhesion kinase (FAK) is expressed and if FAK is phosphorylated
in pediatric renal tumors.

OUTLINE:

Archived tumor tissue samples are analyzed for FAK expression by immunohistochemistry (IHC).
IHC staining is compared in normal renal tissue, Wilms tumor (routine and anaplastic),
malignant rhabdoid tumor of the kidney, clear cell sarcoma of the kidney, and mesoblastic
nephroma.

Inclusion Criteria:

- Formalin-fixed, paraffin-embedded tissue samples from patients diagnosed with the
following renal tumors:

- Anaplastic Wilms tumor

- Malignant rhabdoid tumor of the kidney

- Clear cell sarcoma of the kidney

- Mesoblastic nephroma
We found this trial at
1
site
Children's Oncology Group
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
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