Vitamin D Homeostasis in Sarcoidosis
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Food Studies, Endocrine |
| Therapuetic Areas: | Endocrinology, Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 2/17/2019 |
| Start Date: | July 1, 2019 |
| End Date: | December 30, 2023 |
| Contact: | Connie Hsia, MD |
| Email: | Connie.Hsia@utsouthwestern.edu |
| Phone: | 2146483426 |
This study evaluates the relationship between vitamin-D status and severity of sarcoidosis,
and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis.
Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard
vitamin-D supplementation via standard regimen while the other half will receive a placebo.
Sarcoidosis patients who are vitamin-D sufficient will also act as controls.
and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis.
Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard
vitamin-D supplementation via standard regimen while the other half will receive a placebo.
Sarcoidosis patients who are vitamin-D sufficient will also act as controls.
Sarcoidosis is a multi-system inflammatory disease characterized by T-helper lymphocyte
hyperactivity leading to granulomatous inflammation. The granuloma cells autonomously convert
25-hydroxy-vitamin-D (25OHD) to the active metabolite 1,25-dihydroxy-vitamin-D (1,25OH2D)
independent of normal feedback control but dependent on substrate (25OHD) concentration.
Circulating 1,25OH2D exerts both anti-inflammatory and mineral metabolic actions. Deficiency
of 25OHD limits substrate-dependent 1,25OH2D synthesis, diminishes anti-antigenic innate
immunity and augments pro-inflammatory adaptive immunity. Thus, low vitamin-D stores could
aggravate sarcoid inflammation while repletion of vitamin-D stores could mitigate
inflammation in sarcoidosis.
hyperactivity leading to granulomatous inflammation. The granuloma cells autonomously convert
25-hydroxy-vitamin-D (25OHD) to the active metabolite 1,25-dihydroxy-vitamin-D (1,25OH2D)
independent of normal feedback control but dependent on substrate (25OHD) concentration.
Circulating 1,25OH2D exerts both anti-inflammatory and mineral metabolic actions. Deficiency
of 25OHD limits substrate-dependent 1,25OH2D synthesis, diminishes anti-antigenic innate
immunity and augments pro-inflammatory adaptive immunity. Thus, low vitamin-D stores could
aggravate sarcoid inflammation while repletion of vitamin-D stores could mitigate
inflammation in sarcoidosis.
Inclusion Criteria:
- Stable medical condition defined as no hospitalization or emergency room visit in the
previous 3 months
- No evidence of active pulmonary or systemic infection
- No other active inflammatory disease,
- No active malignancy.
- Normal serum ionized calcium level
Exclusion Criteria:
- Hospitalization or emergency room visit in the previous 3 months
- Evidence of active pulmonary or systemic infection
- Evidence of active other inflammatory disease
- Evidence of active malignancy
- Elevated serum ionized calcium level
We found this trial at
1
site
Dallas, Texas 75390
Click here to add this to my saved trials
