Awake vs. Asleep Craniotomy for Non-eloquent Gliomas

This is a single-center, prospective randomized open or non-blinded end-point (PROBE)
clinical trial. Patients will be selected by the neurosurgeon according to the inclusion and
exclusion criteria. Patients who consent to randomization will have confirmed non-eloquent
status confirmed by independent surgeon and will be randomized into 1 of 2 treatment groups
utilizing a dynamic minimization approach. The experimental group with randomization of
patients who will undergo awake craniotomy for both high and low grade gliomas in
non-eloquent areas or a control group of patients who will have asleep craniotomy for both
high and low grade gliomas in non-eloquent regions.

INCLUSION CRITERIA

1. Patients with age ≥18 years old.

2. WHO grade I, II, III, and IV Glioma in non-eloquent brain cortex based on magnetic
resonance imaging (MRI)

3. An elective procedure.

4. A single lesion.

5. No major comorbidities that would necessitate an extended hospital stay.

6. Newly diagnosed tumors.

EXCLUSION CRITERIA

1. Patients with age < 18 years old.

2. Non-gliomas

3. Eloquent location (motor, sensory, language)

4. Non-elective procedure.

5. Multiple lesions.

6. Major comorbidities.

7. Recurrent tumors.

8. Patients lacking capacity to consent.