Fluoxetine for Visual Recovery After Ischemic Stroke

Inclusion Criteria:

- MRI-confirmed acute ischemic stroke resulting in an isolated homonymous visual field
loss.

Exclusion Criteria:

- Known hypersensitivity to fluoxetine or other selective serotonin reuptake inhibitors

- National Institutes of Health Stroke Scale score greater than 5

- Premorbid modified Rankin Scale score greater than 2

- Premorbid monocular or binocular visual field deficits

- Premorbid retinopathy or optic neuropathy

- Premorbid depression

- History of cognitive impairment, dementia, or neurodegenerative disorder

- History of seizure disorder

- History of mania or hypomania

- History of hyponatremia

- History of angle-closure glaucoma or elevated intraocular pressure

- Current alcohol abuse or impaired liver function

- Current use of an antidepressant medication

- Current use of a medication likely to have an adverse interaction with fluoxetine

- Current use of a medication likely to impair post-stroke recovery

- Contraindication to MRI

- Pregnancy or lactation

- Hemorrhagic transformation of the index stroke, resulting in mass effect

- Enrollment in another clinical trial at the time of the index stroke