Drug-drug Interaction Study of Ozanimod With Inhibitor or Inducer of CYP2C8 and/or CYP3A

Inclusion Criteria:

1. Subject is a man or non-pregnant, non-lactating woman, ages 18 to 55 years, inclusive,
at the time of signing of the informed consent form (ICF).

2. Female subjects must meet at least 1 of the following criteria:

- Negative serum pregnancy test at Screening and Day -1 (women of child-bearing
potential [WOCBP] only).

- Postmenopausal (defined as 2 years after the last period and follicle-stimulating
hormone [FSH] > 40 IU/L).

- Received surgical sterilization (eg, bilateral tubal ligation, bilateral
oophorectomy, hysterectomy) at least 6 months before Screening with medical
records.

3. Females of child-bearing potential:

Must agree to practice a highly effective method of contraception throughout the study
until completion of the 75-day Safety Follow-up. Highly effective methods of
contraception are those that alone or in combination result in a failure rate of a
Pearl index of less than 1% per year when used consistently and correctly.

Acceptable methods of birth control in this study are the following:

- Combined hormonal (oestrogen and progestogen containing) contraception, which may
be oral, intravaginal, or transdermal

- Progestogen-only hormonal contraception associated with inhibition of ovulation,
which may be oral, injectable, implantable

- Placement of an intrauterine device or intrauterine hormone-releasing system

- Bilateral tubal occlusion

- Vasectomized partner

- Sexual abstinence

Male subjects:

Must agree to use a latex condom with spermicide during sexual contact with WOCBP
while participating in the study and until completion of the 75-day Safety Follow-up.

All subjects:

Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal
(coitus interruptus), spermicides only, and lactational amenorrhea method are not
acceptable methods of contraception. Female condom and male condom should not be used
together.

4. Male subjects must agree to refrain from donating sperm throughout the study and until
completion of the 75-day Safety Follow-up.

5. Subject has a body weight of at least 110 pounds (50 kg); body mass index (BMI) within
the range of 18.0 to 30.0 kg/m2, inclusive (Screening and Day -1).

6. Subject is in good health, as determined by no clinically significant findings from
medical or surgical history, 12-lead ECG, physical examination, clinical laboratory
tests, and vital signs.

7. Subject must be able to comprehend and provide written informed consent, and must be
able to comply with the requirements of the study, including the study visit schedule
and other protocol requirements.

Exclusion Criteria:

1. Subject with a seated blood pressure outside 90 to 140 mmHg systolic or 50 to 90 mmHg
diastolic at Screening or Day -1.

2. Subject with a seated pulse rate outside 55 to 90 bpm at Screening or Day -1.

3. Subject has a presence or history of any abnormality or illness that, in the opinion
of the investigator, may affect absorption, distribution, metabolism, or elimination
of the Investigational product (IP) or would limit the subject's ability to
participate in and complete this clinical study.

4. Subject has a history of alcoholism, drug abuse, or addiction within 24 months prior
to Screening.

5. Subject has a positive serum test for human immunodeficiency virus (HIV), hepatitis B
virus (HBV), or hepatitis C virus (HCV).

6. Subject has used any tobacco- or nicotine-containing products (including but not
limited to cigarettes, pipes, cigars, electronic cigarettes, vape, chewing tobacco,
nicotine patches, nicotine lozenges, or nicotine gum) or marijuana (cigarette, joint,
vape, edibles, etc) within 3 months prior to the first dose of IP.

7. Subject has a positive urine drug test including cotinine at Screening or Day -1.

8. Subject has a positive alcohol urine or breath test at Screening or Day -1.

9. Subject has received any investigational drug within 30 days or 5 times the
elimination half-life (if known), whichever is longer, prior to the first dose of IP.

10. Subject has used any systemic over-the-counter medication (excluding acetaminophen up
to 1 g/day), dietary or herbal supplement (excluding vitamins/multivitamins) within 7
days prior to the first dose of IP. St. John's wort, naringenin, curcurmin/turmeric,
passion flower, and quercetin must be discontinued at least 28 days prior to the first
dose of IP.

11. Subject has used any systemic prescription medication (excluding hormonal
contraceptives) within 28 days or 5 times the elimination half-life, whichever is
longer, prior to the first dose of IP.

12. Subject has ingested alcohol within 7 days prior to the first dose of IP.

13. Subject fails or is unwilling to abstain from strenuous physical activities for at
least 24 hours prior to the first dose of IP.

14. Subject has poor peripheral venous access.

15. Subject has donated greater than 400 mL of blood within 60 days prior to Day 1.

16. Subject has a history of any medical condition or medical history that, in the opinion
of the investigator, might confound the results of the study or jeopardize the safety
or welfare of the subject.

17. Subject has history of hypersensitivity or allergic reaction to S1P receptor
modulators (both Parts 1 and 2), gemfibrozil (Part 1 only), itraconazole or other
azole antifungals (Part 2 only), or rifampin (Part 2 only).

18. Subject has a history of gall bladder disease (Part 2 only).