Macrolide Antibiotic Therapy for Patients With Cystic Fibrosis
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 6 - 50 |
| Updated: | 8/15/2018 |
| Start Date: | December 2000 |
| End Date: | October 2004 |
The purpose of this study is to evaluate whether Biaxin (clarithromycin) improves sputum
abnormalities, lung function, and overall feeling of well-being in people with cystic
fibrosis (CF). Biaxin is an antibiotic commonly used for the treatment of respiratory
infections in people who do not have CF, and is sometimes used in CF patients as well.
Studies done in a disease called diffuse panbronchiolitis (which is similar to CF) and some
preliminary studies that have been done in CF patients suggest that Biaxin might have a
beneficial effect on CF sputum in ways unrelated to its antibiotic activity.
abnormalities, lung function, and overall feeling of well-being in people with cystic
fibrosis (CF). Biaxin is an antibiotic commonly used for the treatment of respiratory
infections in people who do not have CF, and is sometimes used in CF patients as well.
Studies done in a disease called diffuse panbronchiolitis (which is similar to CF) and some
preliminary studies that have been done in CF patients suggest that Biaxin might have a
beneficial effect on CF sputum in ways unrelated to its antibiotic activity.
Inclusion Criteria:
- diagnosis of CF
- ability to reliably perform spirometry
- FEV1 of 30% predicted at the time of screening
Exclusion Criteria:
- Mycobacterium in a sputum culture ever recorded
- a respiratory exacerbation requiring IV antibiotics in the 60 days prior
- used a investigational drug or device in the 60 days prior
- significant (>30ml) of hemoptysis in the past year
- require oxygen or have significant liver or renal disease
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
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