Management of Uncontrolled Hypertension (HTN)
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 8/15/2018 |
| Start Date: | January 2017 |
| End Date: | September 2019 |
| Contact: | Katherine Vogel Anderson, Pharm D |
| Email: | kvanderson@cop.ufl.edu |
| Phone: | 352-273-6240 |
Management of Uncontrolled Hypertension: Ambulatory Blood Pressure Monitoring and Subsequent Modification of Therapy or Shifting Anti-hypertensive Medication to Night-time Dosing
In this study, investigators will compare chronotherapy to ABPM. Data collected will include
hypertension drug therapy regimen prior to and during the study, timing of medication
administration, and dose, along with the patient's office blood pressure values prior to
study and one month after modification in therapy. This will enable us to explore whether it
is a practical endeavor to implement ABPM as a routine process for all uncontrolled
hypertension patients or whether ABPM does not seem to provide considerable value over
shifting the timing of drug administration.
hypertension drug therapy regimen prior to and during the study, timing of medication
administration, and dose, along with the patient's office blood pressure values prior to
study and one month after modification in therapy. This will enable us to explore whether it
is a practical endeavor to implement ABPM as a routine process for all uncontrolled
hypertension patients or whether ABPM does not seem to provide considerable value over
shifting the timing of drug administration.
Investigators propose to conduct a pilot study to determine whether the incorporation of
Ambulatory Blood Pressure Monitoring (ABPM) as routine procedure in clinic for uncontrolled
hypertension influences how anti-hypertensive drug therapy is modified or if simply shifting
the dosing of anti-hypertensive medications to night time achieves similar results.
Investigators will enroll 20 participants with uncontrolled hypertension, who are prescribed
3 anti-hypertensive medications at maximum dose. All twenty patients will undergo 24-hour
blood pressure monitoring with ABPM at baseline and one month after change in therapy has
been initiated; ten of the patients will be randomized to receive a shift in dosing schedule
of anti-hypertensive medication to night-time without utilizing their ABPM results while the
remaining ten will receive modifications in therapy based on their ABPM results and dipping
status. The results of this study will assist in assessing the feasibility and benefits of
the incorporation of ABPM into the routine management of hypertension.
Ambulatory Blood Pressure Monitoring (ABPM) as routine procedure in clinic for uncontrolled
hypertension influences how anti-hypertensive drug therapy is modified or if simply shifting
the dosing of anti-hypertensive medications to night time achieves similar results.
Investigators will enroll 20 participants with uncontrolled hypertension, who are prescribed
3 anti-hypertensive medications at maximum dose. All twenty patients will undergo 24-hour
blood pressure monitoring with ABPM at baseline and one month after change in therapy has
been initiated; ten of the patients will be randomized to receive a shift in dosing schedule
of anti-hypertensive medication to night-time without utilizing their ABPM results while the
remaining ten will receive modifications in therapy based on their ABPM results and dipping
status. The results of this study will assist in assessing the feasibility and benefits of
the incorporation of ABPM into the routine management of hypertension.
Inclusion Criteria:
- Age ≥ 18 years
- Blood pressure of >140/90 mmHg for patients less than 60 years or >150/90 for patients
60 years or older
- Currently receiving 3 anti-hypertensive agents, one of which is a diuretic, for at
least 3 months
Exclusion Criteria:
- Pregnant women
- Prisoners
- Cognitively impaired persons
- Minorities
- Economically and/or educationally disadvantaged
- Human fetuses and neonates
- Children
- Conditions with visual field deterioration (Anterior Ischemic Optic Neuropathy,
Glaucoma, Optic Nerve Disorders)
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