Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
| Status: | Completed |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 8/16/2018 |
| Start Date: | November 2003 |
| End Date: | October 2007 |
The Comparison of Morphine and Hydromorphone Patient-Controlled Analgesia
Both morphine and hydromorphone are pain medications commonly used after surgery. It is
thought at the institution that hydromorphone causes less side effects but this has not been
studied. The study proposes to treat the patients with either morphine or hydromorphone and
determine how much nausea, vomiting, and itching they have with each drug
thought at the institution that hydromorphone causes less side effects but this has not been
studied. The study proposes to treat the patients with either morphine or hydromorphone and
determine how much nausea, vomiting, and itching they have with each drug
Inclusion Criteria:
- patients scheduled for abdominal surgery requiring post-operative PCA
- ASA = I or II
Exclusion Criteria:
- preoperative pain or use of pain medication
- narcotic allergy
- morbid obesity (Body Mass Index > 30)
- diagnosis of sleep apnea
- hepatic or renal disease
- use of medications that would affect narcotic pharmacodynamics
- preoperative nausea, vomiting, or pruritis
- diagnosis of alcoholism
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