Impact of Slowly Digestible Carbohydrates on Gastric Emptying Rates
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/16/2018 |
| Start Date: | September 15, 2018 |
| End Date: | February 15, 2019 |
| Contact: | Bruce R Hamaker, PhD |
| Email: | hamakerb@purdue.edu |
| Phone: | 765.494.5668 |
Consumption of slowly digestible carbohydrates can elicit higher satiety feeling compared to
rapidly digestible carbohydrates, however not all individuals respond the same. The
physiological mechanism that accounts for the satiety effect and the lack of consistency
among subjects is not fully understood. The overall aim of this research is to determine if
consumption of slow digestible carbohydrates (e.g., millet couscous) can induce
non-responding subjects (i.e., with rapid gastric emptying) to activate the ileal brake and
delay rate of gastric emptying.
rapidly digestible carbohydrates, however not all individuals respond the same. The
physiological mechanism that accounts for the satiety effect and the lack of consistency
among subjects is not fully understood. The overall aim of this research is to determine if
consumption of slow digestible carbohydrates (e.g., millet couscous) can induce
non-responding subjects (i.e., with rapid gastric emptying) to activate the ileal brake and
delay rate of gastric emptying.
The purpose of this study is to understand how consumption of slowly digestible carbohydrate
(e.g. millet couscous) over time may affect overall health. The investigators will be
recruiting 15 volunteers for this study. To be eligible for this study, you need to be
between 18 and 50 years old, have a normal Body Mass Index, have a normal fasting blood
glucose level, be free of any gastrointestinal diseases, diabetes, cardiovascular diseases,
be free of wheat allergens, gluten intolerance or sensitivities, and allergy to millet, and
not be pregnant or nursing. If you have any questions about the criteria, please ask the
person consenting you.
In this study participants will consume 200-300 g slowly digestible carbohydrates/day for 30
days. For the duration of the study there will be 5 testing days, in which participants will
consume a meal with a C13 tracer, breath into test bags and wear a glucose monitor. During
testing days participants will be required to stay in the laboratory. Testing day sessions
will last about 4 hours with a short 30-minute visit the day prior to install glucose
monitor. For non-testing days participants will consume meal in the laboratory but are not
required to stay. The purpose of this study is to evaluate the continuous effect of slowly
digestible carbohydrates consumption on gastric emptying and its potential health benefits.
(e.g. millet couscous) over time may affect overall health. The investigators will be
recruiting 15 volunteers for this study. To be eligible for this study, you need to be
between 18 and 50 years old, have a normal Body Mass Index, have a normal fasting blood
glucose level, be free of any gastrointestinal diseases, diabetes, cardiovascular diseases,
be free of wheat allergens, gluten intolerance or sensitivities, and allergy to millet, and
not be pregnant or nursing. If you have any questions about the criteria, please ask the
person consenting you.
In this study participants will consume 200-300 g slowly digestible carbohydrates/day for 30
days. For the duration of the study there will be 5 testing days, in which participants will
consume a meal with a C13 tracer, breath into test bags and wear a glucose monitor. During
testing days participants will be required to stay in the laboratory. Testing day sessions
will last about 4 hours with a short 30-minute visit the day prior to install glucose
monitor. For non-testing days participants will consume meal in the laboratory but are not
required to stay. The purpose of this study is to evaluate the continuous effect of slowly
digestible carbohydrates consumption on gastric emptying and its potential health benefits.
Inclusion Criteria:
BMI 18.5 - 25.0 kg/m2 18 - 50 years Normal fasting blood glucose
Exclusion Criteria:
- History of gastrointestinal disease Diabetes Pregnant and nursing women Wheat and/or
gluten allergies or sensitivities Allergy to specific sources of slowly digestible
carbohydrates
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