Angelica Gigas Dietary Supplements and Human Immune Cells
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 2/22/2019 |
| Start Date: | February 6, 2019 |
| End Date: | August 2020 |
| Contact: | Deepkamal N Karelia, Ph.D. |
| Email: | dkarelia@pennstatehealth.psu.edu |
| Phone: | 717-531-0003 |
Study of Angelica Gigas Dietary Supplements (Cogni.Q) and Potential Effects on Human Immune Cells
This human study will test the impact of dietary supplement vegicaps containing Korean
Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and
other germs and natural killer (NK) cells that kill virus-infected cells and cancers. The
investigators had done an earlier study with Korean Angelica supplement and discovered even a
single dose of it increased blood neutrophils and NK cells within 24 h. In the new study,
Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo)
capsules. This is to make sure the immune boosting actions are really from the Korean
Angelica supplement.
Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and
other germs and natural killer (NK) cells that kill virus-infected cells and cancers. The
investigators had done an earlier study with Korean Angelica supplement and discovered even a
single dose of it increased blood neutrophils and NK cells within 24 h. In the new study,
Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo)
capsules. This is to make sure the immune boosting actions are really from the Korean
Angelica supplement.
Inclusion Criteria:
- Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in
the range of 19 to 30
- Subjects having normal hepatic, renal function as assessed by history, physical and
clinical chemistry analysis (CMP eGFR, see supporting document for normal reference
ranges).
- Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80
mm Hg)
Exclusion Criteria:
- Subjects positive for HIV, HBV and HCV (self-reported)
- Subjects taking any kind of prescription medications regularly or within 10 days of
the study will be excluded. Therefore, subjects with diabetes, major cardiovascular
diseases, cancer, severe hypertension, severe hepatic cirrhosis or cirrhosis of the
liver, and kidney disease (self-reported) will be excluded.
- Subjects using tobacco products, nicotine patches and excessive alcohol
- Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q,
Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10
days of the study.
- Non-English-speaking subjects
We found this trial at
1
site
Hershey, Pennsylvania 17033
Principal Investigator: Junxuan Lu, Ph.D.
Click here to add this to my saved trials
