Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Brain Cancer, Brain Cancer, Brain Cancer, Neurology |
| Therapuetic Areas: | Neurology, Oncology |
| Healthy: | No |
| Age Range: | 1 - 25 |
| Updated: | 8/17/2018 |
| Start Date: | October 2009 |
| End Date: | August 2019 |
Neurobehavioral Functioning and Utilization of Special Education Services in Pediatric Brain and CNS Tumor Patients After Proton Radiation Treatment: A Longitudinal Study
The aim of this study is to follow up with all of the pediatric brain tumor patients who
received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which
there is baseline neuropsychological testing in order to measure changes, if any, in
neurobehavioral functioning (executive skills, emotional/behavioral functioning, and adaptive
abilities) and their use of special education services at one year or more post-treatment.
The investigators will also correlate neurobehavioral data with pertinent clinical
information. Participation will be maximized through the use of mail-in, parental- and
self-report questionnaires.
received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which
there is baseline neuropsychological testing in order to measure changes, if any, in
neurobehavioral functioning (executive skills, emotional/behavioral functioning, and adaptive
abilities) and their use of special education services at one year or more post-treatment.
The investigators will also correlate neurobehavioral data with pertinent clinical
information. Participation will be maximized through the use of mail-in, parental- and
self-report questionnaires.
The purpose of this study is to longitudinally examine neurobehavioral functioning outcomes
and use of special education services in brain tumor and CNS tumor patients treated with
proton radiation at MGH. Furthermore, we seek to correlate neurobehavioral data with
pertinent clinical information. We anticipate better neurobehavioral functioning to be
associated with use of protons (vs. photons, as reported in the literature). We also
anticipate the need and utilization of special education services to be lower in brain and
CNS tumor patients treated with protons (vs. photons, as reported in the literature). Lastly,
we anticipate greater neurobehavioral deficits in patients whose proton radiation treatment
involved the craniospinal axis compared to those who received proton radiation to the
involved field.
and use of special education services in brain tumor and CNS tumor patients treated with
proton radiation at MGH. Furthermore, we seek to correlate neurobehavioral data with
pertinent clinical information. We anticipate better neurobehavioral functioning to be
associated with use of protons (vs. photons, as reported in the literature). We also
anticipate the need and utilization of special education services to be lower in brain and
CNS tumor patients treated with protons (vs. photons, as reported in the literature). Lastly,
we anticipate greater neurobehavioral deficits in patients whose proton radiation treatment
involved the craniospinal axis compared to those who received proton radiation to the
involved field.
Inclusion Criteria:
1. Children diagnosed with brain or CNS tumors and treated with proton radiation therapy
at the MGH Francis H. Burr Proton Center since September 2002
2. Patients received baseline neurocognitive testing at MGH
3. Patients ≤25 years at the time of diagnosis
4. Tumor location in the brain or CNS
5. Radiation treatment consisted of only proton radiotherapy
6. No prior radiation exposure or chemotherapy
Exclusion Criteria:
1. Patients receiving treatment with palliative intent
2. Patients who do not wish to participate
3. Patient is deceased at ≥1 year follow-up
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