Energy Expenditure & Activity During & After Exercise-Induced Weight Loss
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 5/30/2018 |
| Start Date: | September 2007 |
| End Date: | December 2020 |
This project is aimed at determining whether an exercise-based weight loss intervention
causes a compensation in some component of energy expenditure such that the increase in
measured energy expenditure is less than the added exercise. The study will compare two
separate exercise interventions to determine if this is influenced by exercise intensity.
causes a compensation in some component of energy expenditure such that the increase in
measured energy expenditure is less than the added exercise. The study will compare two
separate exercise interventions to determine if this is influenced by exercise intensity.
The primary aim of this proposed study is to determine how total daily activity thermogenesis
(TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans attempting to
lose weight and maintain weight loss through exercise. Two exercise interventions will be
compared; a structured aerobic exercise program and a walking program. exercise activity
thermogenesis (EAT) will be verified, and non-exercise physical activity (NEAT), total daily
activity thermogenesis (TDAT), and TDEE will be measured using state-of-the-art technologies.
Subjects will be studied during a 6 month intervention period and then during a 6 month
follow-up period. It is hypothesized that the walking program will have more favorable
effects on TDAT and TDEE during both the intervention and follow-up periods. If the
investigators hypotheses are correct, then data from the proposed study could be used to
improve the effectiveness of exercise-based weight loss and weight loss maintenance programs.
(TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans attempting to
lose weight and maintain weight loss through exercise. Two exercise interventions will be
compared; a structured aerobic exercise program and a walking program. exercise activity
thermogenesis (EAT) will be verified, and non-exercise physical activity (NEAT), total daily
activity thermogenesis (TDAT), and TDEE will be measured using state-of-the-art technologies.
Subjects will be studied during a 6 month intervention period and then during a 6 month
follow-up period. It is hypothesized that the walking program will have more favorable
effects on TDAT and TDEE during both the intervention and follow-up periods. If the
investigators hypotheses are correct, then data from the proposed study could be used to
improve the effectiveness of exercise-based weight loss and weight loss maintenance programs.
Inclusion Criteria
- Body mass index (BMI) 30-35.0 kg/m2
- Age 18-45 years
- Weight stable (<2 kg weight fluctuation during previous 6 months)
- No regular exercise (> 1 bout of exercise/wk or participation in any sporting
activities > 1 hr/wk)
- No self-report of acute or chronic disease (diabetes, heart diseases, and joint
problems in particular)
- No current use of prescribed medications
- No plans to relocate within the next year
- No plans for extended travel (> 1 week) within the next 6 months
- No tobacco use
For Females:
- No evidence of amenorrhea (Regular menstrual cycles of 21-35 days)
- Pre-menopausal status (self-report, to be confirmed during screening)
- Pregnancy or lactating within the past year
- No pregnancy or planned pregnancies; sexually active women of childbearing potential
may be enrolled if they have had a tubal ligation or use one of the following means of
contraception: condom, diaphragm, oral or implanted contraceptives, or intrauterine
device. Women in exclusive relationships with male partners who have had a successful
vasectomy will not be required to use any additional means of birth control.
Exclusion Criteria:
- Claustrphobia;
- Any contraindication(s) to > MRI, e.g. aneurysm, cochlear implant, cardiac pacemaker,
or implantable cardiac defibrillator, artificial heart valve, metallic stents, any
implantable devices or shunt, weight less than 300 lbs;
- Left Handed.
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