Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?
| Status: | Recruiting |
|---|---|
| Conditions: | Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 12/21/2018 |
| Start Date: | August 2016 |
| End Date: | December 2018 |
| Contact: | SOE NAING, MD |
| Email: | snaing@fresno.ucsf.edu |
| Phone: | (559) 459-4390 |
Is the Stepping-down Approach a Better Option Than Multiple Daily Injections in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?
In traditional step-up approach, the patients with poorly-controlled type 2 diabetes are
instructed to take up to 4 insulin injections daily or multiple daily injections (MDI) as the
most advanced therapy. However, a significant number of these patients continue to have poor
diabetes control. The most common reason is the noncompliance with multiple injections and
the patient's reluctance to accept insulin-induced weight gain. More recently, the algorithm
in diabetes management has significantly changed to accommodate the newer generation of
medications. Addition of the diabetes medications, that can induce weight loss such as oral
Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors and once-weekly glucagon-like peptide
(GLP)-1 receptor agonists (GLP1 RA) injection, to a basal insulin is now recommended before
the patient is advanced to MDI. This approach works very well in most patients since weight
loss gives the patients an extra motivation to take medication regularly. Similarly, the
patient does not require to take an insulin injection before each meal throughout the day in
this approach.
Unfortunately, there are still a large number of patients with poor glycemic control who are
still on MDI. Some of them were initiated on MDI before the availability of newer generations
of medications. Some were started simply because the physician was not aware of or not the
familiar with the new recommendations. Regardless of the reason, these patients are likely to
remain on MDI despite chronic poor glycemic control since the physicians are understandably
reluctant to step down the most advanced insulin therapy. In addition, there has been no data
on the benefits and safety of the stepping-down approach from the most advanced insulin
therapy to the more patient-friendly approach that is the combined use of oral SGLT2i and
once-weekly GLP1 RA injection.
instructed to take up to 4 insulin injections daily or multiple daily injections (MDI) as the
most advanced therapy. However, a significant number of these patients continue to have poor
diabetes control. The most common reason is the noncompliance with multiple injections and
the patient's reluctance to accept insulin-induced weight gain. More recently, the algorithm
in diabetes management has significantly changed to accommodate the newer generation of
medications. Addition of the diabetes medications, that can induce weight loss such as oral
Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors and once-weekly glucagon-like peptide
(GLP)-1 receptor agonists (GLP1 RA) injection, to a basal insulin is now recommended before
the patient is advanced to MDI. This approach works very well in most patients since weight
loss gives the patients an extra motivation to take medication regularly. Similarly, the
patient does not require to take an insulin injection before each meal throughout the day in
this approach.
Unfortunately, there are still a large number of patients with poor glycemic control who are
still on MDI. Some of them were initiated on MDI before the availability of newer generations
of medications. Some were started simply because the physician was not aware of or not the
familiar with the new recommendations. Regardless of the reason, these patients are likely to
remain on MDI despite chronic poor glycemic control since the physicians are understandably
reluctant to step down the most advanced insulin therapy. In addition, there has been no data
on the benefits and safety of the stepping-down approach from the most advanced insulin
therapy to the more patient-friendly approach that is the combined use of oral SGLT2i and
once-weekly GLP1 RA injection.
A prospective, randomized, open-label, controlled, parallel-group trial is planned. This
study is an interdepartmental collaborative study among the Department of Internal Medicine,
Department of Family & Community Medicine (UCSF Fresno), Sierra Vista Family Medicine
Residency Program and Division of Endocrinology.
The study will be conducted at the following multiple locations in order to maximize the
patient recruitment:
1. Internal medicine clinic at Derian Koligian ambulatory care center (ACC)
2. Family practice medicine clinic at ACC
3. Diabetes clinic at ACC
4. Internal medicine clinic at University Medicine Associates in East medical Plaza
5. Endocrine clinic at University Medicine Associates in East medical Plaza
6. Sierra Vista clinics
The patients will be recruited during the first 12 months of the study or until the
predetermined sample size is reached, whichever comes first.
The patient's primary care provider will be informed of the enrollment in the study if the
participant gives the permission to do so.
All participants in both group will need to make all 3 visits to UCSF Clinical Research
Center over 16- week period.
(1) First visit: Once the site co-investigators identify the suitable and interested study
patient, a trained research coordinator will contact the patient for the first visit. The
patient will be seen at the UCSF Clinical Research Center by the research coordinator and a
physician co-investigator.
During the first visit, all patients in both group will
- be given the information about the study.
- sign the consent form.
- be randomly assigned to either treatment (i.e. Step Down) or control (MDI) group by
using A Randomization Plan from http://www.randomization.com.
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
Medication changes at first visit:
In treatment group,
1. All prandial insulin injections (Humalog, Novolog, Apidra, Novolin R or Humulin R),
usually 3 times daily before meals, will be discontinued.
2. Basal insulin (NPH, Lantus, Levimir, Toujeo or Tresiba), usually once daily at bed time,
will be continued at 80 % of the home dose. The dose will be gradually increased until
the patient is back on the home dose (the dose that the patient has been taking at home
prior to the enrollment) or fasting BG of 80-130mg/dl is achieved by using the
self-titration regimen.
3. If the patient is on pre-mixed basal+prandial insulin 2-3 times daily, it will be
discontinued and a basal insulin alone, (NPH, Lantus, Levemir, Toujeo or Tresiba), will
be given at 40% of total daily dose of pre-mixed insulin. The dose will be gradually
increased until fasting BG of 80-130mg/dl is achieved by using the self-titration
regimen.
4. Metformin, that most patients are expected to be on, will be continued, but other
non-insulin oral medications for diabetes will be discontinued. If the patient is not on
metformin, then Metformin ER will be started at 500mg with a meal for 2 weeks as a
routine care and then 1000mg daily as a maintenance dose if tolerated.
5. Both SGLT2i and GLP1 RA will be added to metformin and a basal insulin.
The patient will be trained on the injection technique of the once-weekly GLP1 RA, potential
side effects, risk and benefits of all new medications in detail, hypoglycemia management and
the self-titration regimen for the basal insulin.
In the control group, there will not be any change in MDI therapy, and the participants will
continue to have the usual and standard care through the primary care provider. The
participants should not receive SGLT2i and GLP1 RA during the study period.
(2) Second visit: At 4 weeks after the patient starts taking new medications, the patients
will make the 2nd visit to the UCSF Clinical Research Center.
During the 2nd visit, the patient in the treatment group will
- be enquired about any side effect of the medications.
- be reviewed on insulin dose and the use of self-titration regimen for the basal insulin.
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
In the control group, there will not be any change in MDI therapy, and the participants will
continue to have the usual and standard care through the primary care provider. The
participants should not receive SGLT2i and GLP1 RA during the study period.
During the 2nd visit, the patient in the control group will
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
(3) Third visit: The patients will make the 3rd or final visit to the UCSF Clinical
Research Center at 12 weeks after 2nd visit or 16 weeks from the date of the start of
both SGLT2i and a GLP1 RA.
During the 3rd visit, the patients in both groups will
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
The investigators will try to make a clinic appointment with primary care provider one month
prior to the last visit to the research center for those who are in the treatment group if
the patient gives the permission to do so. Therefore the primary care provider will be able
to order the medications through the patient's health insurance plan if the patient wishes to
remain on the study medications beyond the study period. Alternatively, the patients can go
back on insulin therapy that was given prior to the study.
Monitoring of the treatment group:
The patients in both groups will monitor FPGs daily at minimum. The research coordinator will
call all participants in both groups at weeks 1, 2, 8, and 12 to review fasting glucose
measurements, ask for possible adverse events, incidents of hypoglycemia, and any change in
medication.
All participants in both groups in both groups will be reviewed again at the UCSF Clinical
Research Center at weeks #4 and #16 for both blood tests and physical examinations.
Outcome measurements:
The primary outcome is the change in A1c at the end of 16 weeks of study period and secondary
outcomes are the changes in fasting blood glucose, weight, blood pressure, heart rate,
fasting lipids, serum sodium and potassium, serum creatinine, liver enzymes, CBC, medication
adherence scores and treatment satisfaction scores . These changes will be compared between
the two independent groups, namely the treatment group and the control group, and also within
the same group.
Blood test and questionnaire:
The following blood work will be drawn and analyzed at the community regional medical center
at baseline (first visit), at 4 weeks and at the end of the study at 16 weeks:
1. A1c
2. Complete Blood Count (CBC) with differential
3. Complete metabolic panel (CMP)
4. Fasting lipid profile
Patient satisfaction with treatment in both groups will be measured by the validated the
Diabetes Medications Satisfaction (DM-SAT) Questionnaire form.
Patient adherence will be determined by using the Brief Medication Questionnaire (BMQ).
SAMPLE SIZE AND ANALYSIS PLAN:
The investigators will attempt to recruit and consent 20 patients in each arm that was
calculated to provide an 80% statistical power at a 0.05 alpha in this continuous endpoint,
two independent sample study.
The calculation was based on the following:
A mean Hemoglobin A1c of 8.5±1% at the initiation of the study period. In the treatment group
we anticipate a decline in Hemoglobin A1c of 12-15% by the end of the study period. The
standard deviation for the mean A1c was derived from the literature.
The data will be analyzed by using SPSS software. Significance testing will be conducted at
the two-sided 5% level. Continuous variables will be examined for normality and if assumption
is met, differences in mean values will be tested using Student's t test an analysis of
variance (ANOVA). If not normally distributed, non-parametric procedures will be used,
including Wilcoxan rank Sum test. Categorical data will be analyzed using Fisher's exact test
and Chi square analysis. Since before/after comparisons will also be performed on the same
study patients we will utilize paired t tests and McNemar's chi-square test.
study is an interdepartmental collaborative study among the Department of Internal Medicine,
Department of Family & Community Medicine (UCSF Fresno), Sierra Vista Family Medicine
Residency Program and Division of Endocrinology.
The study will be conducted at the following multiple locations in order to maximize the
patient recruitment:
1. Internal medicine clinic at Derian Koligian ambulatory care center (ACC)
2. Family practice medicine clinic at ACC
3. Diabetes clinic at ACC
4. Internal medicine clinic at University Medicine Associates in East medical Plaza
5. Endocrine clinic at University Medicine Associates in East medical Plaza
6. Sierra Vista clinics
The patients will be recruited during the first 12 months of the study or until the
predetermined sample size is reached, whichever comes first.
The patient's primary care provider will be informed of the enrollment in the study if the
participant gives the permission to do so.
All participants in both group will need to make all 3 visits to UCSF Clinical Research
Center over 16- week period.
(1) First visit: Once the site co-investigators identify the suitable and interested study
patient, a trained research coordinator will contact the patient for the first visit. The
patient will be seen at the UCSF Clinical Research Center by the research coordinator and a
physician co-investigator.
During the first visit, all patients in both group will
- be given the information about the study.
- sign the consent form.
- be randomly assigned to either treatment (i.e. Step Down) or control (MDI) group by
using A Randomization Plan from http://www.randomization.com.
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
Medication changes at first visit:
In treatment group,
1. All prandial insulin injections (Humalog, Novolog, Apidra, Novolin R or Humulin R),
usually 3 times daily before meals, will be discontinued.
2. Basal insulin (NPH, Lantus, Levimir, Toujeo or Tresiba), usually once daily at bed time,
will be continued at 80 % of the home dose. The dose will be gradually increased until
the patient is back on the home dose (the dose that the patient has been taking at home
prior to the enrollment) or fasting BG of 80-130mg/dl is achieved by using the
self-titration regimen.
3. If the patient is on pre-mixed basal+prandial insulin 2-3 times daily, it will be
discontinued and a basal insulin alone, (NPH, Lantus, Levemir, Toujeo or Tresiba), will
be given at 40% of total daily dose of pre-mixed insulin. The dose will be gradually
increased until fasting BG of 80-130mg/dl is achieved by using the self-titration
regimen.
4. Metformin, that most patients are expected to be on, will be continued, but other
non-insulin oral medications for diabetes will be discontinued. If the patient is not on
metformin, then Metformin ER will be started at 500mg with a meal for 2 weeks as a
routine care and then 1000mg daily as a maintenance dose if tolerated.
5. Both SGLT2i and GLP1 RA will be added to metformin and a basal insulin.
The patient will be trained on the injection technique of the once-weekly GLP1 RA, potential
side effects, risk and benefits of all new medications in detail, hypoglycemia management and
the self-titration regimen for the basal insulin.
In the control group, there will not be any change in MDI therapy, and the participants will
continue to have the usual and standard care through the primary care provider. The
participants should not receive SGLT2i and GLP1 RA during the study period.
(2) Second visit: At 4 weeks after the patient starts taking new medications, the patients
will make the 2nd visit to the UCSF Clinical Research Center.
During the 2nd visit, the patient in the treatment group will
- be enquired about any side effect of the medications.
- be reviewed on insulin dose and the use of self-titration regimen for the basal insulin.
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
In the control group, there will not be any change in MDI therapy, and the participants will
continue to have the usual and standard care through the primary care provider. The
participants should not receive SGLT2i and GLP1 RA during the study period.
During the 2nd visit, the patient in the control group will
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
(3) Third visit: The patients will make the 3rd or final visit to the UCSF Clinical
Research Center at 12 weeks after 2nd visit or 16 weeks from the date of the start of
both SGLT2i and a GLP1 RA.
During the 3rd visit, the patients in both groups will
- have the blood test for A1c, CMP, CBC, fasting lipid and measurements of body weight,
height, blood pressure, and heart rate.
- complete both the Diabetes Medications Satisfaction (DM-SAT) Questionnaire form and the
Brief Medication Questionnaire (BMQ).
The investigators will try to make a clinic appointment with primary care provider one month
prior to the last visit to the research center for those who are in the treatment group if
the patient gives the permission to do so. Therefore the primary care provider will be able
to order the medications through the patient's health insurance plan if the patient wishes to
remain on the study medications beyond the study period. Alternatively, the patients can go
back on insulin therapy that was given prior to the study.
Monitoring of the treatment group:
The patients in both groups will monitor FPGs daily at minimum. The research coordinator will
call all participants in both groups at weeks 1, 2, 8, and 12 to review fasting glucose
measurements, ask for possible adverse events, incidents of hypoglycemia, and any change in
medication.
All participants in both groups in both groups will be reviewed again at the UCSF Clinical
Research Center at weeks #4 and #16 for both blood tests and physical examinations.
Outcome measurements:
The primary outcome is the change in A1c at the end of 16 weeks of study period and secondary
outcomes are the changes in fasting blood glucose, weight, blood pressure, heart rate,
fasting lipids, serum sodium and potassium, serum creatinine, liver enzymes, CBC, medication
adherence scores and treatment satisfaction scores . These changes will be compared between
the two independent groups, namely the treatment group and the control group, and also within
the same group.
Blood test and questionnaire:
The following blood work will be drawn and analyzed at the community regional medical center
at baseline (first visit), at 4 weeks and at the end of the study at 16 weeks:
1. A1c
2. Complete Blood Count (CBC) with differential
3. Complete metabolic panel (CMP)
4. Fasting lipid profile
Patient satisfaction with treatment in both groups will be measured by the validated the
Diabetes Medications Satisfaction (DM-SAT) Questionnaire form.
Patient adherence will be determined by using the Brief Medication Questionnaire (BMQ).
SAMPLE SIZE AND ANALYSIS PLAN:
The investigators will attempt to recruit and consent 20 patients in each arm that was
calculated to provide an 80% statistical power at a 0.05 alpha in this continuous endpoint,
two independent sample study.
The calculation was based on the following:
A mean Hemoglobin A1c of 8.5±1% at the initiation of the study period. In the treatment group
we anticipate a decline in Hemoglobin A1c of 12-15% by the end of the study period. The
standard deviation for the mean A1c was derived from the literature.
The data will be analyzed by using SPSS software. Significance testing will be conducted at
the two-sided 5% level. Continuous variables will be examined for normality and if assumption
is met, differences in mean values will be tested using Student's t test an analysis of
variance (ANOVA). If not normally distributed, non-parametric procedures will be used,
including Wilcoxan rank Sum test. Categorical data will be analyzed using Fisher's exact test
and Chi square analysis. Since before/after comparisons will also be performed on the same
study patients we will utilize paired t tests and McNemar's chi-square test.
Inclusion Criteria:
The following patients with diabetes mellitus type 2 who can give written consent will be
eligible for enrollment. They must meet all criteria.
1. > 21 years of age
2. Body mass index (BMI) ≥30 kg/m2
3. On insulin at least 2 times daily comprising both a basal and a prandial insulin or a
pre-mix insulin with or without other non-insulin medications for a least past 3
months
4. A1c >8%
5. eGFR >45%
Exclusion Criteria:
The patients with any of the following criteria will be excluded.
1. Any patient who does not meet the above inclusion criteria.
2. Pregnancy
3. Patients who are on a SGLT2i and a GLP1 RA injection at the time of enrollment.
4. diabetes mellitus type 1
5. C-peptide below normal range if measured in the past.
6. patients with a history of diabetes ketoacidosis
7. A history of recent and frequent (≥ 2 times within past 3 months) urinary tract
infection or genito-urinary candidiasis requiring antibiotic and/or anti-fungal
therapies.
8. a personal or family history of medullary thyroid carcinoma (MTC) or in patients with
Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
9. eGFR <45%
10. patients with a history of acute pancreatitis
We found this trial at
1
site
