Global Electrical Heterogeneity and Clinical Outcomes

Status:	Active, not recruiting
Conditions:	Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - 89
Updated:	8/23/2018
Start Date:	July 1, 2017
End Date:	June 30, 2020

This retrospective multicenter cohort will validate an independent association of
electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained
ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients
with primary prevention ICD, and will validate and re-calibrate GEH ECG risk score for
prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in
systolic heart failure patients with primary prevention ICD.

Inclusion Criteria:

- records of systolic heart failure patients with primary prevention ICDs/CRT-Ds
implanted for routine clinical indications

Exclusion Criteria:

- absent baseline pre-implant digital ECG;

- missing data on clinical predictors and covariates;

- missing ICD programming data (including number of intervals to detect [NID] or time to
detect, number of detection zones, heart rate for each detection zone, and
anti-tachycardia pacing [ATP] programming);

- missing outcomes data.

- records of patients with inherited channelopathies (e.g. long QT syndrome, Brugada
syndrome), inherited cardiomyopathies (e.g. hypertrophic cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy), and congenital heart disease.

We found this trial at

sites

Cleveland Clinic

9500 Euclid Avenue
Cleveland, Ohio 44106

216.444.2200