The Evolution of Memories Across Wake and Sleep
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 3/21/2019 |
| Start Date: | March 1, 2016 |
| End Date: | June 20, 2021 |
To further understanding of the relationship between sleep and memory the investigators will
address and attempt to answer three questions, (1) how memories evolve across wake and sleep,
(2) how different aspects of this memory evolution are reflected both behaviorally and in the
EEG signal, and (3) what stages and features of sleep affect memory evolution. Together,
these studies will provide a greater breadth and depth of knowledge concerning sleep's role
in memory consolidation. Such knowledge would be of practical importance for educational
practices, whether in schools, on the job, or in the military, and would also provide
valuable information to the fields of sleep medicine and psychiatry, where interactions
between sleep disorders and cognitive functioning are of great importance.
address and attempt to answer three questions, (1) how memories evolve across wake and sleep,
(2) how different aspects of this memory evolution are reflected both behaviorally and in the
EEG signal, and (3) what stages and features of sleep affect memory evolution. Together,
these studies will provide a greater breadth and depth of knowledge concerning sleep's role
in memory consolidation. Such knowledge would be of practical importance for educational
practices, whether in schools, on the job, or in the military, and would also provide
valuable information to the fields of sleep medicine and psychiatry, where interactions
between sleep disorders and cognitive functioning are of great importance.
Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how
specific memories are selected for change across periods of wake and sleep, and in
characterizing the manner in which those memories change. There has been research into broad
areas of memory, such as procedural and declarative memory, but other forms of memory, such
as semantic memory, remain unexplored, as well as different subtypes of memory within these
broad areas. Additionally, it is presently unknown how memories are selected for subsequent
processing during sleep and wake. The investigators aim to characterize which memories
change, how they are selected, and how they change differently over periods that include
sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators
will employ and develop specific behavioral and electrophysiological tasks and measures that
allow one to probe the state of a particular type of memory and determine how it changes over
periods of wake and sleep. EEG signals may be informative about the status of a memory during
behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which
sleep in particular is found or suspected to influence memories in a unique way, the
investigators will assess which stages and features of sleep are involved in that evolution.
Generally, this will be accomplished by correlating measures such as time spent in a sleep
stage, prominence of particular brain oscillations, or density of spindles with changes in
behavior or in other EEG metrics
specific memories are selected for change across periods of wake and sleep, and in
characterizing the manner in which those memories change. There has been research into broad
areas of memory, such as procedural and declarative memory, but other forms of memory, such
as semantic memory, remain unexplored, as well as different subtypes of memory within these
broad areas. Additionally, it is presently unknown how memories are selected for subsequent
processing during sleep and wake. The investigators aim to characterize which memories
change, how they are selected, and how they change differently over periods that include
sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators
will employ and develop specific behavioral and electrophysiological tasks and measures that
allow one to probe the state of a particular type of memory and determine how it changes over
periods of wake and sleep. EEG signals may be informative about the status of a memory during
behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which
sleep in particular is found or suspected to influence memories in a unique way, the
investigators will assess which stages and features of sleep are involved in that evolution.
Generally, this will be accomplished by correlating measures such as time spent in a sleep
stage, prominence of particular brain oscillations, or density of spindles with changes in
behavior or in other EEG metrics
Inclusion Criteria:
- willing and able to follow the protocol
- willing to refrain from alcohol and recreational drugs for the duration of the
protocol
- in some cases, English as a first language, normal hearing, and/or normal or corrected
to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- a history of mental illness
- the use of any drugs that could affect either sleep or cognitive functioning (e.g.,
sleeping pills or antidepressants)
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