Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
| Status: | Completed |
|---|---|
| Conditions: | Ovarian Cancer, Other Indications, Women's Studies, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Oncology, Other, Reproductive |
| Healthy: | No |
| Age Range: | 16 - 48 |
| Updated: | 8/25/2018 |
| Start Date: | July 2012 |
| End Date: | October 2013 |
The purpose of this study is to investigate the mechanism that explain the beneficial
clinical effect of vitamin D treatment in women with PCOS.
clinical effect of vitamin D treatment in women with PCOS.
Seventy-nine women with (n=22) or without (control; n=57) PCOS who were diagnosed with
vitamin D deficiency were enrolled. Sixty-three women were replaced with oral vit D3 for 8
weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10
controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured
at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the
non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were
used as appropriate.
Main outcome measure(s): Changes in serum sRAGE and AMH concentrations following vit D3
replacement.
vitamin D deficiency were enrolled. Sixty-three women were replaced with oral vit D3 for 8
weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10
controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured
at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the
non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were
used as appropriate.
Main outcome measure(s): Changes in serum sRAGE and AMH concentrations following vit D3
replacement.
Inclusion Criteria:
- Vitamin D deficient premenopausal women
Exclusion Criteria:
- Pregnant women
- Women during their postpartum period
- Breastfeeding women
- Women taking any kind of exogenous hormones
- Women receiving any form of oral vitamin D replacement
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