Postmenopausal Women and Their Endothelium
| Status: | Recruiting |
|---|---|
| Conditions: | Postmenopausal Syndrome, Women's Studies |
| Therapuetic Areas: | Endocrinology, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/10/2018 |
| Start Date: | November 7, 2018 |
| End Date: | September 3, 2024 |
| Contact: | David N Proctor, PhD |
| Email: | dnp3@psu.edu |
| Phone: | 814-863-0724 |
Postmenopausal Women and Their Endothelium: Is Acute Dietary Nitrate Supplementation Protective
The purpose of this study is to test the effects of a one time dose of inorganic nitrate
(supplied in the form of beetroot juice) on blood vessel function and resting blood pressure
in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink
beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel
function will be measured.
(supplied in the form of beetroot juice) on blood vessel function and resting blood pressure
in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink
beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel
function will be measured.
Cardiovascular disease is the leading cause of death in the United States. Due to the loss of
estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors
following menopause. Postmenopausal women represent a population at heightened risk for
cardiovascular disease development. Function of the endothelium has been shown to decline
across the menopause transition, resulting in less production of nitric oxide. As such the
investigators are investigating a potential therapeutic strategy in women have recently
undergone menopause to boost nitric oxide availability.
estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors
following menopause. Postmenopausal women represent a population at heightened risk for
cardiovascular disease development. Function of the endothelium has been shown to decline
across the menopause transition, resulting in less production of nitric oxide. As such the
investigators are investigating a potential therapeutic strategy in women have recently
undergone menopause to boost nitric oxide availability.
Inclusion Criteria:
- Early post-menopausal women who are within 1-5 years following their final menstrual
period
Exclusion Criteria:
- Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal,
musculoskeletal, and/or neurological disease(s).
- Users of any tobacco and/or nicotine products (smokers, chewing tobacco,
nicotine-containing patches/gum, smokeless cigarettes)
- Individuals with a BMI > 35
- Individuals with resting blood pressure > or = 130/80 mm Hg
- Individuals with high blood lipids (total cholesterol > or = 240 mg/dl, LDL > or = 160
mg/dl, triglycerides > or = 200 mg/dl).
- Postmenopausal women with hyperglycemia (fasting glucose > or = 110 mg/dl and HbA1c
>6.0%).
- Individuals taking any of the following medications:
1. blood pressure lowering medication (e.g., beta blockers, ACE inhibitors,
angiotensin antagonists, calcium channel blockers, diuretics)
2. lipid- lowering medication (e.g., statins)
3. nitrates (e.g. nitroglycerin) for angina
4. phosphodiesterase inhibitors (e.g., Viagra)
5. anti-Inflammatory drugs
- Individuals taking hormone therapy
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