Drug-drug Interaction Study of Ozanimod With Pseudoephedrine to Evaluate the Effect on Blood Pressure and Heart Rate

Inclusion Criteria:

1. Subject is a man or non-pregnant, non-lactating woman, aged 18 to 55 years, inclusive,
at the time of signing the informed consent form (ICF).

2. Female subjects must meet at least 1 of the following criteria:

- Negative serum pregnancy test at Screening and Day -2 (women of child-bearing
potential [WOCBP] only).

- Postmenopausal (defined as 2 years after the last period and follicle-stimulating
hormone [FSH] > 40 IU/L).

- Received surgical sterilization (eg, bilateral tubal ligation, bilateral
oophorectomy, hysterectomy) at least 6 months before Screening with medical
records.

3. Females of child-bearing potential:

Must agree to practice a highly effective method of contraception throughout the study
until completion of the 75-day Safety Follow-up. Highly effective methods of
contraception are those that alone or in combination result in a failure rate of a
Pearl index of less than 1% per year when used consistently and correctly.

Acceptable methods of birth control in this study are the following:

- Combined hormonal (estrogen and progestogen containing) contraception, which may
be oral, intravaginal, or transdermal

- Progestogen-only hormonal contraception associated with inhibition of ovulation,
which may be oral, injectable, implantable

- Placement of an intrauterine device or intrauterine hormone-releasing system

- Bilateral tubal occlusion

- Vasectomized partner

- Sexual abstinence

Male subjects:

Must agree to use a latex condom with spermicide during sexual contact with WOCBP
while participating in the study and until completion of the 75-day Safety Follow-up.

All subjects:

Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal
(coitus interruptus), spermicides only, and lactational amenorrhea method are not
acceptable methods of contraception. Female condom and male condom should not be used
together.

4. Male subjects must agree to refrain from donating sperm during the study and until
completion of the 75-day Safety Follow-up.

5. Subject has a body weight of at least 110 pounds (50 kg); body mass index (BMI) within
the range of 18.0 to 30.0 kg/m2, inclusive, at Screening and Day -2.

6. Subject is in good health, as determined by no clinically significant findings from
medical or surgical history, 12-lead ECG, physical examination, clinical laboratory
tests, and vital signs.

7. Subject has a mean systolic blood pressure (SBP) of 90 to 140 mmHg, a diastolic blood
pressure (DBP) of 50 to 90 mmHg from three consecutive measurements at Screening and
Day -2.

8. Subject must be able to comprehend and provide written informed consent, and must be
able to comply with the requirements of the study, including the study visit schedule
and other protocol requirements

Exclusion Criteria:

1. Subject has clinically significant electrocardiogram (ECG) and cardiovascular symptoms
at Screening.

2. Subject has a presence or history of any abnormality or illness that, in the opinion
of the investigator, may affect absorption, distribution, metabolism, or elimination
of the study drugs or would limit the subject's ability to participate in and complete
this clinical study.

3. Subject has a history of clinically significant or unstable vascular disease, or a
history of syncope associated with hypotension within the last 2 years or a history of
orthostatic hypotension (or SBP decrease of ≥ 20 mmHg 2 minutes after standing
compared with supine SBP).

4. Subject with a seated pulse rate outside 55 to 90 beats per minute (bpm) at Screening
or Day -2.

5. Subject with a resting Fridericia-corrected interval between Q and T wave in the
heart's electrical cycle (QTcF) > 450 msec (males) or > 470 msec (females) or interval
from the beginning of the P wave to the beginning of the QRS complex (PR) > 200 msec
at Screening.

6. Subject has a history of alcoholism, drug abuse, or addiction within 24 months prior
to Screening.

7. Subject has a positive serum test for human immunodeficiency virus (HIV), hepatitis B
virus (HBV), or hepatitis C virus (HCV) at Screening.

8. Subject has used any tobacco- or nicotine-containing products (including but not
limited to cigarettes, pipes, cigars, vape, electronic cigarettes, chewing tobacco,
nicotine patches, nicotine lozenges, or nicotine gum) within 3 months prior to the
first dose of IP.

9. Subject has consumed any marijuana products within 3 months prior to the first dose of
IP.

10. Subject has a positive urine drug test including cotinine at Screening or Day -2.

11. Subject has a positive alcohol urine or breath test at Screening or Day -2.

12. Subject has received any investigational drug within 30 days or 5 times the
elimination half-life (if known), whichever is longer, prior to the first dose of IP.

13. Subject has used any systemic over-the-counter medication (excluding acetaminophen up
to 1 g/day), dietary or herbal supplement (excluding vitamins/multi-vitamins) within 7
days prior to the first dose of IP. St. John's wort must be discontinued at least 28
days prior to the first dose of IP.

14. Subject has used any systemic prescription medication (excluding hormonal
contraceptives) within 28 days or 5 times the elimination half-life, whichever is
longer, prior to the first dose of IP.

15. Subject has used any known MAO inhibitors within 90 days prior to the first dose of
IP. 16. Subject has a history of allergic reaction to pseudoephedrine or ozanimod.

17. Subject has ingested alcohol within 7 days prior to the first dose of IP. 18. Subject
plans or will participate in strenuous physical activities during the 24-hour period prior
to the first dose of IP.

19. Subject has poor peripheral venous access. 20. Subject has donated greater than 400 mL
of blood within 60 days prior to the first dose of IP.

21. Subject has a history of any medical history that, in the opinion of the investigator,
might confound the results of the study or jeopardize the safety or welfare of the subject.