Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Neurology, ALS |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 21 - 75 |
| Updated: | 3/27/2019 |
| Start Date: | October 1, 2018 |
| End Date: | March 2020 |
| Contact: | Barbara K Smith, PT, PhD |
| Email: | bksmith@phhp.ufl.edu |
| Phone: | (352) 294-5315 |
This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH)
session on respiratory and non-respiratory motor function and EMG (electromyography) activity
on patients with ALS (amyotrophic lateral sclerosis) and healthy controls.
session on respiratory and non-respiratory motor function and EMG (electromyography) activity
on patients with ALS (amyotrophic lateral sclerosis) and healthy controls.
Most ALS patients survive less than 5 years after diagnosis, and the main cause of death is
respiratory failure. The investigators are interested in the therapeutic potential of acute
intermittent hypoxia (AIH) for individuals with neuromuscular diseases, such as ALS. More
than two decades of research indicates AIH elicits meaningful respiratory and non-respiratory
motor recovery. Acute intermittent hypoxia (AIH) consists of alternating periods of breathing
mildly hypoxic (lowered oxygen concentration) and normoxic (normal oxygen concentration) air.
The investigators propose to study mechanisms of respiratory plasticity associated with a
single presentation of mild AIH. The fundamental hypothesis guiding this proposal is that
even a single AIH trial improves respiratory (and non-respiratory) motor function in ALS
patients procedure. Participants will then be asked to breathe air with reduced oxygen for
short periods of time, for a duration of 45 minutes. The activity of your muscles and your
heart function will be monitored throughout the procedure.
respiratory failure. The investigators are interested in the therapeutic potential of acute
intermittent hypoxia (AIH) for individuals with neuromuscular diseases, such as ALS. More
than two decades of research indicates AIH elicits meaningful respiratory and non-respiratory
motor recovery. Acute intermittent hypoxia (AIH) consists of alternating periods of breathing
mildly hypoxic (lowered oxygen concentration) and normoxic (normal oxygen concentration) air.
The investigators propose to study mechanisms of respiratory plasticity associated with a
single presentation of mild AIH. The fundamental hypothesis guiding this proposal is that
even a single AIH trial improves respiratory (and non-respiratory) motor function in ALS
patients procedure. Participants will then be asked to breathe air with reduced oxygen for
short periods of time, for a duration of 45 minutes. The activity of your muscles and your
heart function will be monitored throughout the procedure.
Inclusion Criteria:
- a healthy adult
- clinical diagnosis of ALS
- baseline FVC >50% predicted for age, sex and height.
Exclusion Criteria:
- pregnant
- diagnosed cardiovascular disease
- a BMI >35 kg/m2
- currently take selective serotonin reuptake inhibitors (SSRI)
- history of seizures
- history of hospitalization for sepsis
- respiratory infection or took antibiotic medications within the past 4 weeks
- use external respiratory support during any waking hours
- participate in a pharmaceutical trial to treat ALS
- have any other medical condition the PI or medical director identify would make it
unsuitable to participate.
We found this trial at
2
sites
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
Click here to add this to my saved trials
Click here to add this to my saved trials