Choline Supplementation and Cardiovascular Health
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 4/6/2019 |
| Start Date: | September 24, 2018 |
| End Date: | November 2019 |
| Contact: | Kevin Davy, PhD |
| Email: | kdavy@vt.edu |
| Phone: | 540-231-3487 |
Acute Choline Supplementation and Cardiovascular Health in Adults
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary
choline, has recently been causally linked to atherosclerosis in animal models and has been
shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort
studies. The relevance of observations in animals to humans is unclear and little information
is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays
a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO
impairs vascular function in humans is not known. The purpose of this study is to determine
if acute supplementation of dietary choline, which increases TMAO, impairs vascular function.
choline, has recently been causally linked to atherosclerosis in animal models and has been
shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort
studies. The relevance of observations in animals to humans is unclear and little information
is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays
a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO
impairs vascular function in humans is not known. The purpose of this study is to determine
if acute supplementation of dietary choline, which increases TMAO, impairs vascular function.
Inclusion Criteria:
- 18-60 years old
- Healthy
- Non-smoking
- Weight stable for previous 6 months (±2.0 kg)
- BMI <35 kg/m^2
- Verbal and written informed consent
- Approved for participation by study medical director (Jose Rivero, M.D.)
Exclusion Criteria:
- Smoking
- Pregnancy
- Obese (BMI>35 kg/m2)
- Altered dietary patterns within the last month of recruitment
- Unstable heart disease or diabetes
- Untreated high blood pressure or high cholesterol
- Allergies to choline
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