Effect of Natural Antioxidant Supplement on Sperm DNA Fragmentation



Status:Recruiting
Healthy:No
Age Range:18 - 55
Updated:8/26/2018
Start Date:August 1, 2018
End Date:July 2021
Contact:Mandy Katz-Jaffe, PhD
Email:rmakloski@colocrm.com
Phone:303-788-8300

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Trial Summary
Trial Overview
Inclusion Criteria

Observation Study of the Effect of Use of Natural Antioxidant Supplement on Sperm DNA Fragmentation

Observational study to see the effect of use of natural Antioxidant supplement on sperm DNA
fragmentation. Subjects will take the natural antioxidant for 3 months prior to repeat
testing.

Male patients will be recruited based on having a high DNA fragmentation (chromatin >16) no
other severe male factor infertility (>5million/ml, count, > 10%motility and >1% morphology)
and sufficient ejaculate sperm for ICSI (no surgically removed sperm or history of vasectomy
reversal). Patients will be provided the natural antioxidant supplementation by the sponsor.
Patients will take 1 capsule orally 3 times a day for a full 12 weeks. Sperm DNA structure
will be re-assessed after completion of 12 weeks of antioxidant to compare to baseline sperm
DNA structure collected prior to starting regimen of supplement daily

Inclusion Criteria:

-Sperm Chromatin >16%, sufficient ejaculate sperm for ICSI

Exclusion Criteria:

- Severe male factor infertility
We found this trial at
1
site
Colorado Center for Reproductive Medicine
Lone Tree, Colorado 18104
?
mi
from
Lone Tree, CO
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