CancerLife: Patient-Driven Solution in Cancer Care

This is a nonblinded, randomized, controlled trial of a digital information and communication
platform (DICP) in self-reporting and monitoring of cancer and cancer-treatment related
symptoms compared with usual care

Patients initiating and/or receiving systemic treatment for cancer will be enrolled in a
nonblinded, randomized, controlled trial of a DICP in self-reporting and monitoring of cancer
and cancer-treatment related symptoms compared with usual care. The study will require one
(1) study encounter for consenting purposes.

All participants entering their information on the registration page will be contacted by a
study team member for informed consent. Eligible subjects who agree to participate in the
study and sign the consent form will be will be screened for eligibility. Participants will
be randomized 1:1 to two arms:

Arm A will be asked to download a mobile application called CancerLife. CancerLife is a
patient facing messaging app that gives cancer survivors and caregivers the ability to update
family and friends of their health status through their existing social networks and at the
same collect psychosocial and symptom reports that can be shared with the patients care team.
Participants will be provided with online or printed instructions on the use of CancerLife
and receive a user guide that they can refer on demand. CancerLife is a stand-alone
application that is NOT integrated into the patient's electronic health record and will NOT
trigger symptom alerts to the treatment team. Participants will be instructed to use the
after-visit instructions provided to them by their treatment team for any symptoms or
conditions that will require an evaluation by a healthcare provider.

Arm B will receive usual care provided for in the clinics. Usual care may vary between
institutions, practices, and providers. Usual care may consist of but is not limited to any
combination of the following: history and physical examination, review of systems, distress
screening, symptom assessment measures, and/or interval quality of life measures.

Participants in Arm A will be asked to register on CancerLife to start using the broadcasting
feature of the app. In addition, they will be asked to complete a series of questions through
CancerLife at baseline and every 3 months for up to 2 years. Participants in Arm A will also
be asked to complete FACT-G, GAD-7, DST, and QQPPI at those timepoints.

Participants in Arm B will receive usual care provided for in the clinics. They will also be
asked to complete the FACT-G, GAD-7, DST, and QQPPI at baseline and every 3 months for up to
2 years..

Inclusion Criteria:

- Age > 18 years

- Diagnosis of cancer

- Receiving systemic treatment (chemotherapy, biotherapy/immunotherapy, hormonal
therapy) that is expected to continue for at least 3 treatment sessions (approximately
9 weeks) from the time of enrollment

- Karnofsky Index ≥50%

- Able to understand and sign informed consent

- Owns and able to use an electronic communication device (smart phone, tablet, laptop,
desktop) and answer simple self-report questionnaires on their own

Exclusion Criteria:

- Relevant cognitive impairment

- Participating in a therapeutic clinical trial

- Unable to read and comprehend English language text